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Association between polymorphisms in the CYP1A1, CYP2E1 and GSTM1 genes, and smoking, alcohol and upper digestive tract carcinomas in a high-incidence area of northern China

Metabolic gene variants, smoking, and alcohol consumption are important upper digestive tract cancer (UDTC) risk factors. However, the gene-gene and gene-environment interactions remain unclear. A case-control study in a high incidence area for upper digestive tract cancer was conducted in China. DN...

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Autores principales: Zhao, Fang, Su, Jing-Fen, Lun, Shu-Min, Hou, Yong-Jie, Duan, Li-Juan, Wang, Neng-Chao, Shen, Fang-Fang, Zhang, Yao-Wen, Gao, Zhao-Wei, Li, Jing, Du, Xian-Juan, Zhou, Fu-You
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607096/
https://www.ncbi.nlm.nih.gov/pubmed/31423187
http://dx.doi.org/10.3892/ol.2019.10455
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author Zhao, Fang
Su, Jing-Fen
Lun, Shu-Min
Hou, Yong-Jie
Duan, Li-Juan
Wang, Neng-Chao
Shen, Fang-Fang
Zhang, Yao-Wen
Gao, Zhao-Wei
Li, Jing
Du, Xian-Juan
Zhou, Fu-You
author_facet Zhao, Fang
Su, Jing-Fen
Lun, Shu-Min
Hou, Yong-Jie
Duan, Li-Juan
Wang, Neng-Chao
Shen, Fang-Fang
Zhang, Yao-Wen
Gao, Zhao-Wei
Li, Jing
Du, Xian-Juan
Zhou, Fu-You
author_sort Zhao, Fang
collection PubMed
description Metabolic gene variants, smoking, and alcohol consumption are important upper digestive tract cancer (UDTC) risk factors. However, the gene-gene and gene-environment interactions remain unclear. A case-control study in a high incidence area for upper digestive tract cancer was conducted in China. DNA was extracted from buffy coat samples for PCR or PCR-restriction fragment length polymorphism. Smoking and alcohol drinking status was determined by questionnaires. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the associations. After adjusting for confounding factors, smoking increased esophageal cancer (EC), gastric cardia cancer (GCC) and gastric antral carcinoma (GAC) risk by 3.594, 4.658, and 3.999-fold, respectively. Alcohol consumption increased EC, GCC and GAC risk by 1.953, 2.442 and 1.765-fold, respectively. The cytochrome P4501A1 (CYP1A1) rs4646903 T>C polymorphism increased GCC risk, the cytochrome P4502E1 (CYP2E1) rs2031920 C>T polymorphism increased EC risk, while the GSTM1 null genotype decreased EC risk. An association existed between the following: CYP1A1 rs4646903 and smoking in EC, GCC and GAC; CYP1A1 rs4646903 and alcohol consumption in EC and GCC; CYP2E1 rs2031920 and smoking in EC, GCC and GAC and CYP2E1 rs2031920 and alcohol consumption in EC and GCC. No association was observed between CYP1A1 and CYP2E1. The glutathione S-transferase mu 1 (GSTM1) null genotype decreased EC risk (OR=0.510). Smoking/drinking are upper digestive tract cancer risk factors. The CYP1A1 rs4646903 and CYP2E1 rs2031920 polymorphisms were risk factors of GCC or EC, and the GSTM1 null genotype may serve a protective role against EC. The results of the present study indicated that gene-environment interactions increase the risk of UDTC.
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spelling pubmed-66070962019-08-18 Association between polymorphisms in the CYP1A1, CYP2E1 and GSTM1 genes, and smoking, alcohol and upper digestive tract carcinomas in a high-incidence area of northern China Zhao, Fang Su, Jing-Fen Lun, Shu-Min Hou, Yong-Jie Duan, Li-Juan Wang, Neng-Chao Shen, Fang-Fang Zhang, Yao-Wen Gao, Zhao-Wei Li, Jing Du, Xian-Juan Zhou, Fu-You Oncol Lett Articles Metabolic gene variants, smoking, and alcohol consumption are important upper digestive tract cancer (UDTC) risk factors. However, the gene-gene and gene-environment interactions remain unclear. A case-control study in a high incidence area for upper digestive tract cancer was conducted in China. DNA was extracted from buffy coat samples for PCR or PCR-restriction fragment length polymorphism. Smoking and alcohol drinking status was determined by questionnaires. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the associations. After adjusting for confounding factors, smoking increased esophageal cancer (EC), gastric cardia cancer (GCC) and gastric antral carcinoma (GAC) risk by 3.594, 4.658, and 3.999-fold, respectively. Alcohol consumption increased EC, GCC and GAC risk by 1.953, 2.442 and 1.765-fold, respectively. The cytochrome P4501A1 (CYP1A1) rs4646903 T>C polymorphism increased GCC risk, the cytochrome P4502E1 (CYP2E1) rs2031920 C>T polymorphism increased EC risk, while the GSTM1 null genotype decreased EC risk. An association existed between the following: CYP1A1 rs4646903 and smoking in EC, GCC and GAC; CYP1A1 rs4646903 and alcohol consumption in EC and GCC; CYP2E1 rs2031920 and smoking in EC, GCC and GAC and CYP2E1 rs2031920 and alcohol consumption in EC and GCC. No association was observed between CYP1A1 and CYP2E1. The glutathione S-transferase mu 1 (GSTM1) null genotype decreased EC risk (OR=0.510). Smoking/drinking are upper digestive tract cancer risk factors. The CYP1A1 rs4646903 and CYP2E1 rs2031920 polymorphisms were risk factors of GCC or EC, and the GSTM1 null genotype may serve a protective role against EC. The results of the present study indicated that gene-environment interactions increase the risk of UDTC. D.A. Spandidos 2019-08 2019-06-07 /pmc/articles/PMC6607096/ /pubmed/31423187 http://dx.doi.org/10.3892/ol.2019.10455 Text en Copyright: © Zhao et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Zhao, Fang
Su, Jing-Fen
Lun, Shu-Min
Hou, Yong-Jie
Duan, Li-Juan
Wang, Neng-Chao
Shen, Fang-Fang
Zhang, Yao-Wen
Gao, Zhao-Wei
Li, Jing
Du, Xian-Juan
Zhou, Fu-You
Association between polymorphisms in the CYP1A1, CYP2E1 and GSTM1 genes, and smoking, alcohol and upper digestive tract carcinomas in a high-incidence area of northern China
title Association between polymorphisms in the CYP1A1, CYP2E1 and GSTM1 genes, and smoking, alcohol and upper digestive tract carcinomas in a high-incidence area of northern China
title_full Association between polymorphisms in the CYP1A1, CYP2E1 and GSTM1 genes, and smoking, alcohol and upper digestive tract carcinomas in a high-incidence area of northern China
title_fullStr Association between polymorphisms in the CYP1A1, CYP2E1 and GSTM1 genes, and smoking, alcohol and upper digestive tract carcinomas in a high-incidence area of northern China
title_full_unstemmed Association between polymorphisms in the CYP1A1, CYP2E1 and GSTM1 genes, and smoking, alcohol and upper digestive tract carcinomas in a high-incidence area of northern China
title_short Association between polymorphisms in the CYP1A1, CYP2E1 and GSTM1 genes, and smoking, alcohol and upper digestive tract carcinomas in a high-incidence area of northern China
title_sort association between polymorphisms in the cyp1a1, cyp2e1 and gstm1 genes, and smoking, alcohol and upper digestive tract carcinomas in a high-incidence area of northern china
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607096/
https://www.ncbi.nlm.nih.gov/pubmed/31423187
http://dx.doi.org/10.3892/ol.2019.10455
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