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Systemic mastocytosis: a rare cause of osteoporosis

A 61-year old female patient who was referred to the endocrine clinic for evaluation of an elevated alkaline phosphatase. She was originally referred to gastroenterology (GI), however no GI causes of elevated alkaline phosphatase was found. Upon fractionation, it was noted that she had elevation in...

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Autores principales: Garla, Vishnu Vardhan, Chaudhary, Kanooz Ul Qadir, Yaqub, Abid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607299/
https://www.ncbi.nlm.nih.gov/pubmed/31303938
http://dx.doi.org/10.11604/pamj.2019.32.169.16640
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author Garla, Vishnu Vardhan
Chaudhary, Kanooz Ul Qadir
Yaqub, Abid
author_facet Garla, Vishnu Vardhan
Chaudhary, Kanooz Ul Qadir
Yaqub, Abid
author_sort Garla, Vishnu Vardhan
collection PubMed
description A 61-year old female patient who was referred to the endocrine clinic for evaluation of an elevated alkaline phosphatase. She was originally referred to gastroenterology (GI), however no GI causes of elevated alkaline phosphatase was found. Upon fractionation, it was noted that she had elevation in bone specific alkaline phosphatase. Past history was significant for hypertension, atrial fibrillation and menopause 6 years ago. She was also noted to have multiple drug allergies manifesting as urticaria and flushing. Review of the past records revealed a persistently elevated alkaline phosphatase over the last two years. She had no history of falls or fractures. Computed tomography (CT) abdomen done to rule out biliary pathology, revealed osteosclerotic and osteolytic lesion in the pelvis concerning neoplastic disease. Bone marrow biopsy however, was negative for cancer but consistent with systemic mastocytosis (SM). Dual Energy X-ray absorbimetery (DEXA) scan revealed osteoporosis Serum tryptase levels were elevated; further genetic analysis showed a positive CKIT D816 mutation. She was started on bisphosphonates (initially alendronate and then ibandronate). Upon follow up at two years she had not experienced any fractures and her bone mineral density also had improved significantly.
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spelling pubmed-66072992019-07-12 Systemic mastocytosis: a rare cause of osteoporosis Garla, Vishnu Vardhan Chaudhary, Kanooz Ul Qadir Yaqub, Abid Pan Afr Med J Case Report A 61-year old female patient who was referred to the endocrine clinic for evaluation of an elevated alkaline phosphatase. She was originally referred to gastroenterology (GI), however no GI causes of elevated alkaline phosphatase was found. Upon fractionation, it was noted that she had elevation in bone specific alkaline phosphatase. Past history was significant for hypertension, atrial fibrillation and menopause 6 years ago. She was also noted to have multiple drug allergies manifesting as urticaria and flushing. Review of the past records revealed a persistently elevated alkaline phosphatase over the last two years. She had no history of falls or fractures. Computed tomography (CT) abdomen done to rule out biliary pathology, revealed osteosclerotic and osteolytic lesion in the pelvis concerning neoplastic disease. Bone marrow biopsy however, was negative for cancer but consistent with systemic mastocytosis (SM). Dual Energy X-ray absorbimetery (DEXA) scan revealed osteoporosis Serum tryptase levels were elevated; further genetic analysis showed a positive CKIT D816 mutation. She was started on bisphosphonates (initially alendronate and then ibandronate). Upon follow up at two years she had not experienced any fractures and her bone mineral density also had improved significantly. The African Field Epidemiology Network 2019-04-09 /pmc/articles/PMC6607299/ /pubmed/31303938 http://dx.doi.org/10.11604/pamj.2019.32.169.16640 Text en © Vishnu Vardhan Garla et al. http://creativecommons.org/licenses/by/2.0/ The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Garla, Vishnu Vardhan
Chaudhary, Kanooz Ul Qadir
Yaqub, Abid
Systemic mastocytosis: a rare cause of osteoporosis
title Systemic mastocytosis: a rare cause of osteoporosis
title_full Systemic mastocytosis: a rare cause of osteoporosis
title_fullStr Systemic mastocytosis: a rare cause of osteoporosis
title_full_unstemmed Systemic mastocytosis: a rare cause of osteoporosis
title_short Systemic mastocytosis: a rare cause of osteoporosis
title_sort systemic mastocytosis: a rare cause of osteoporosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607299/
https://www.ncbi.nlm.nih.gov/pubmed/31303938
http://dx.doi.org/10.11604/pamj.2019.32.169.16640
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