“CHOICES”: An acronym to aid in delineating potential causes of non-metabolic, non-infectious acute toxic leukoencephalopathy

PURPOSE: To describe non-metabolic, non-infectious etiologies of acute toxic leukoencephalopathy (ATL) on DWI MRI, and provide a useful acronym to remember them. MATERIAL AND METHODS: Our PACS archive was reviewed, yielding 185 patients with suspected ATL per MRI reports and clinical follow up; infe...

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Detalles Bibliográficos
Autores principales: Koksel, Yasemin, Ozutemiz, Can, Rykken, Jeffrey, Ott, Frederick, Cayci, Zuzan, Oswood, Mark, McKinney, Alexander M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607360/
https://www.ncbi.nlm.nih.gov/pubmed/31309133
http://dx.doi.org/10.1016/j.ejro.2019.06.005
Descripción
Sumario:PURPOSE: To describe non-metabolic, non-infectious etiologies of acute toxic leukoencephalopathy (ATL) on DWI MRI, and provide a useful acronym to remember them. MATERIAL AND METHODS: Our PACS archive was reviewed, yielding 185 patients with suspected ATL per MRI reports and clinical follow up; infectious or metabolic causes were excluded. RESULT/DISCUSSION: The 87 included non-infectious, non-metabolic ATL patients' etiologies are represented by the acronym 'CHOICES': chemotherapy ('C',n = 34); heroin-induced ('H',n = 6), opioid analogues ('O',n = 14); immunosuppressant ('I',n = 11) or imidazole (n = 2); cocaine ('C',n = 1); environmental or ethanol abuse ('E',n = 5), splenial lesions ('S',n = 9), and 'other' (n = 5). CONCLUSION: The "CHOICES" acronym delineates various toxic etiologies of ATL.

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