Cargando…
A Surveillance, Epidemiology and End Results database analysis of the prognostic value of organ-specific metastases in patients with advanced prostatic adenocarcinoma
Prostate cancer (PCa) survival markedly decreases with the occurrence of distant metastasis, and treatment decisions can be influenced by metastasis site, and affect patient survival outcomes. The aim of the present study was to evaluate the potential prognostic value of metastasis to specific sites...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607368/ https://www.ncbi.nlm.nih.gov/pubmed/31423166 http://dx.doi.org/10.3892/ol.2019.10461 |
_version_ | 1783432083218104320 |
---|---|
author | Deng, Yuyou Bi, Ran Zhu, Zhenhua Li, Shengxian Xu, Bo Rather, Wakeel Ahmad Wang, Chunxi |
author_facet | Deng, Yuyou Bi, Ran Zhu, Zhenhua Li, Shengxian Xu, Bo Rather, Wakeel Ahmad Wang, Chunxi |
author_sort | Deng, Yuyou |
collection | PubMed |
description | Prostate cancer (PCa) survival markedly decreases with the occurrence of distant metastasis, and treatment decisions can be influenced by metastasis site, and affect patient survival outcomes. The aim of the present study was to evaluate the potential prognostic value of metastasis to specific sites and the prognostic value of prostatectomy in patients with only bone metastasis, and to determine potential risk factors for bone metastasis in prostatic adenocarcinoma using large scale clinical data. The Surveillance, Epidemiology and End Results (SEER) database (2010–2013) was queried via the SEER*Stat (version 8.3.4) program. A total of 210,730 prostatic adenocarcinoma patients were identified from the SEER database between January 2010 and December 2013. Univariate and multivariate Cox regression analysis and Kaplan-Meier curves were used for survival comparisons with corresponding 95% confidence intervals. Patients with PCa with only liver metastatic lesions had worse overall and cancer-specific survival rates compared with those patients with only bone or lung metastasis. Multivariate Cox regression analysis revealed that age <50 years, married status, T1 and T3 tumor stage according to Tumor-Node-Metastasis (TNM) staging system from the 7th AJCC cancer staging manual, and prostatectomy were associated with better overall survival and cancer-specific survival in patients with only bone metastasis. Binary logistic regression analysis revealed that unmarried status, African descent and undifferentiated histological grade were risk factors for PCa bone metastasis. Prostatic adenocarcinoma patients with only liver metastasis had worse prognostic outcomes compared with patients with other distant organ metastases. Prostatectomy improved the 3-year survival rate in stage IV PCa patients and stage IV PCa patients with only bone metastasis. These findings were based on large-scale clinical data and can provide novel perspectives for the treatment of patients with advanced prostate adenocarcinoma. |
format | Online Article Text |
id | pubmed-6607368 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-66073682019-08-18 A Surveillance, Epidemiology and End Results database analysis of the prognostic value of organ-specific metastases in patients with advanced prostatic adenocarcinoma Deng, Yuyou Bi, Ran Zhu, Zhenhua Li, Shengxian Xu, Bo Rather, Wakeel Ahmad Wang, Chunxi Oncol Lett Articles Prostate cancer (PCa) survival markedly decreases with the occurrence of distant metastasis, and treatment decisions can be influenced by metastasis site, and affect patient survival outcomes. The aim of the present study was to evaluate the potential prognostic value of metastasis to specific sites and the prognostic value of prostatectomy in patients with only bone metastasis, and to determine potential risk factors for bone metastasis in prostatic adenocarcinoma using large scale clinical data. The Surveillance, Epidemiology and End Results (SEER) database (2010–2013) was queried via the SEER*Stat (version 8.3.4) program. A total of 210,730 prostatic adenocarcinoma patients were identified from the SEER database between January 2010 and December 2013. Univariate and multivariate Cox regression analysis and Kaplan-Meier curves were used for survival comparisons with corresponding 95% confidence intervals. Patients with PCa with only liver metastatic lesions had worse overall and cancer-specific survival rates compared with those patients with only bone or lung metastasis. Multivariate Cox regression analysis revealed that age <50 years, married status, T1 and T3 tumor stage according to Tumor-Node-Metastasis (TNM) staging system from the 7th AJCC cancer staging manual, and prostatectomy were associated with better overall survival and cancer-specific survival in patients with only bone metastasis. Binary logistic regression analysis revealed that unmarried status, African descent and undifferentiated histological grade were risk factors for PCa bone metastasis. Prostatic adenocarcinoma patients with only liver metastasis had worse prognostic outcomes compared with patients with other distant organ metastases. Prostatectomy improved the 3-year survival rate in stage IV PCa patients and stage IV PCa patients with only bone metastasis. These findings were based on large-scale clinical data and can provide novel perspectives for the treatment of patients with advanced prostate adenocarcinoma. D.A. Spandidos 2019-08 2019-06-07 /pmc/articles/PMC6607368/ /pubmed/31423166 http://dx.doi.org/10.3892/ol.2019.10461 Text en Copyright: © Deng et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Deng, Yuyou Bi, Ran Zhu, Zhenhua Li, Shengxian Xu, Bo Rather, Wakeel Ahmad Wang, Chunxi A Surveillance, Epidemiology and End Results database analysis of the prognostic value of organ-specific metastases in patients with advanced prostatic adenocarcinoma |
title | A Surveillance, Epidemiology and End Results database analysis of the prognostic value of organ-specific metastases in patients with advanced prostatic adenocarcinoma |
title_full | A Surveillance, Epidemiology and End Results database analysis of the prognostic value of organ-specific metastases in patients with advanced prostatic adenocarcinoma |
title_fullStr | A Surveillance, Epidemiology and End Results database analysis of the prognostic value of organ-specific metastases in patients with advanced prostatic adenocarcinoma |
title_full_unstemmed | A Surveillance, Epidemiology and End Results database analysis of the prognostic value of organ-specific metastases in patients with advanced prostatic adenocarcinoma |
title_short | A Surveillance, Epidemiology and End Results database analysis of the prognostic value of organ-specific metastases in patients with advanced prostatic adenocarcinoma |
title_sort | surveillance, epidemiology and end results database analysis of the prognostic value of organ-specific metastases in patients with advanced prostatic adenocarcinoma |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607368/ https://www.ncbi.nlm.nih.gov/pubmed/31423166 http://dx.doi.org/10.3892/ol.2019.10461 |
work_keys_str_mv | AT dengyuyou asurveillanceepidemiologyandendresultsdatabaseanalysisoftheprognosticvalueoforganspecificmetastasesinpatientswithadvancedprostaticadenocarcinoma AT biran asurveillanceepidemiologyandendresultsdatabaseanalysisoftheprognosticvalueoforganspecificmetastasesinpatientswithadvancedprostaticadenocarcinoma AT zhuzhenhua asurveillanceepidemiologyandendresultsdatabaseanalysisoftheprognosticvalueoforganspecificmetastasesinpatientswithadvancedprostaticadenocarcinoma AT lishengxian asurveillanceepidemiologyandendresultsdatabaseanalysisoftheprognosticvalueoforganspecificmetastasesinpatientswithadvancedprostaticadenocarcinoma AT xubo asurveillanceepidemiologyandendresultsdatabaseanalysisoftheprognosticvalueoforganspecificmetastasesinpatientswithadvancedprostaticadenocarcinoma AT ratherwakeelahmad asurveillanceepidemiologyandendresultsdatabaseanalysisoftheprognosticvalueoforganspecificmetastasesinpatientswithadvancedprostaticadenocarcinoma AT wangchunxi asurveillanceepidemiologyandendresultsdatabaseanalysisoftheprognosticvalueoforganspecificmetastasesinpatientswithadvancedprostaticadenocarcinoma AT dengyuyou surveillanceepidemiologyandendresultsdatabaseanalysisoftheprognosticvalueoforganspecificmetastasesinpatientswithadvancedprostaticadenocarcinoma AT biran surveillanceepidemiologyandendresultsdatabaseanalysisoftheprognosticvalueoforganspecificmetastasesinpatientswithadvancedprostaticadenocarcinoma AT zhuzhenhua surveillanceepidemiologyandendresultsdatabaseanalysisoftheprognosticvalueoforganspecificmetastasesinpatientswithadvancedprostaticadenocarcinoma AT lishengxian surveillanceepidemiologyandendresultsdatabaseanalysisoftheprognosticvalueoforganspecificmetastasesinpatientswithadvancedprostaticadenocarcinoma AT xubo surveillanceepidemiologyandendresultsdatabaseanalysisoftheprognosticvalueoforganspecificmetastasesinpatientswithadvancedprostaticadenocarcinoma AT ratherwakeelahmad surveillanceepidemiologyandendresultsdatabaseanalysisoftheprognosticvalueoforganspecificmetastasesinpatientswithadvancedprostaticadenocarcinoma AT wangchunxi surveillanceepidemiologyandendresultsdatabaseanalysisoftheprognosticvalueoforganspecificmetastasesinpatientswithadvancedprostaticadenocarcinoma |