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Phrenic nerve stimulation to treat patients with central sleep apnoea and heart failure
AIMS: The presence of central sleep apnoea (CSA) is associated with poor prognosis in patients with heart failure (HF). The aim of this analysis was to evaluate if using phrenic nerve stimulation to treat CSA in patients with CSA and HF was associated with changes in HF‐specific metrics. METHODS AND...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607512/ https://www.ncbi.nlm.nih.gov/pubmed/30303611 http://dx.doi.org/10.1002/ejhf.1312 |
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author | Costanzo, Maria Rosa Ponikowski, Piotr Coats, Andrew Javaheri, Shahrokh Augostini, Ralph Goldberg, Lee R. Holcomb, Richard Kao, Andrew Khayat, Rami N. Oldenburg, Olaf Stellbrink, Christoph McKane, Scott Abraham, William T. |
author_facet | Costanzo, Maria Rosa Ponikowski, Piotr Coats, Andrew Javaheri, Shahrokh Augostini, Ralph Goldberg, Lee R. Holcomb, Richard Kao, Andrew Khayat, Rami N. Oldenburg, Olaf Stellbrink, Christoph McKane, Scott Abraham, William T. |
author_sort | Costanzo, Maria Rosa |
collection | PubMed |
description | AIMS: The presence of central sleep apnoea (CSA) is associated with poor prognosis in patients with heart failure (HF). The aim of this analysis was to evaluate if using phrenic nerve stimulation to treat CSA in patients with CSA and HF was associated with changes in HF‐specific metrics. METHODS AND RESULTS: All patients randomized in the remedē System Pivotal Trial and identified at baseline with HF were included (n = 96). Effectiveness data from treatment and former control groups were pooled based on months since therapy activation. Changes from baseline to 6 and 12 months in sleep metrics, Epworth Sleepiness Scale, patient global assessment health‐related quality of life, Minnesota Living with Heart Failure Questionnaire (MLHFQ), and echocardiographic parameters are reported. HF hospitalization, cardiovascular death, and the composite of HF hospitalization or cardiovascular death within 6 months are reported by the original randomized group assignment for safety assessment. Sleep metrics and quality of life improved from baseline to 6 and 12 months. At 12 months, MLHFQ scores changed by –6.8 ± 20.0 (P = 0.005). The 6‐month rate of HF hospitalization was 4.7% in treatment patients (standard error = 3.3) and 17.0% in control patients (standard error = 5.5) (P = 0.065). Reported adverse events were as expected for a transvenous implantable system. CONCLUSIONS: Phrenic nerve stimulation reduces CSA severity in patients with HF. In parallel, this CSA treatment was associated with benefits on HF quality of life. |
format | Online Article Text |
id | pubmed-6607512 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-66075122019-07-16 Phrenic nerve stimulation to treat patients with central sleep apnoea and heart failure Costanzo, Maria Rosa Ponikowski, Piotr Coats, Andrew Javaheri, Shahrokh Augostini, Ralph Goldberg, Lee R. Holcomb, Richard Kao, Andrew Khayat, Rami N. Oldenburg, Olaf Stellbrink, Christoph McKane, Scott Abraham, William T. Eur J Heart Fail New Devices AIMS: The presence of central sleep apnoea (CSA) is associated with poor prognosis in patients with heart failure (HF). The aim of this analysis was to evaluate if using phrenic nerve stimulation to treat CSA in patients with CSA and HF was associated with changes in HF‐specific metrics. METHODS AND RESULTS: All patients randomized in the remedē System Pivotal Trial and identified at baseline with HF were included (n = 96). Effectiveness data from treatment and former control groups were pooled based on months since therapy activation. Changes from baseline to 6 and 12 months in sleep metrics, Epworth Sleepiness Scale, patient global assessment health‐related quality of life, Minnesota Living with Heart Failure Questionnaire (MLHFQ), and echocardiographic parameters are reported. HF hospitalization, cardiovascular death, and the composite of HF hospitalization or cardiovascular death within 6 months are reported by the original randomized group assignment for safety assessment. Sleep metrics and quality of life improved from baseline to 6 and 12 months. At 12 months, MLHFQ scores changed by –6.8 ± 20.0 (P = 0.005). The 6‐month rate of HF hospitalization was 4.7% in treatment patients (standard error = 3.3) and 17.0% in control patients (standard error = 5.5) (P = 0.065). Reported adverse events were as expected for a transvenous implantable system. CONCLUSIONS: Phrenic nerve stimulation reduces CSA severity in patients with HF. In parallel, this CSA treatment was associated with benefits on HF quality of life. John Wiley & Sons, Ltd 2018-10-10 2018-12 /pmc/articles/PMC6607512/ /pubmed/30303611 http://dx.doi.org/10.1002/ejhf.1312 Text en © 2018 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | New Devices Costanzo, Maria Rosa Ponikowski, Piotr Coats, Andrew Javaheri, Shahrokh Augostini, Ralph Goldberg, Lee R. Holcomb, Richard Kao, Andrew Khayat, Rami N. Oldenburg, Olaf Stellbrink, Christoph McKane, Scott Abraham, William T. Phrenic nerve stimulation to treat patients with central sleep apnoea and heart failure |
title | Phrenic nerve stimulation to treat patients with central sleep apnoea and heart failure |
title_full | Phrenic nerve stimulation to treat patients with central sleep apnoea and heart failure |
title_fullStr | Phrenic nerve stimulation to treat patients with central sleep apnoea and heart failure |
title_full_unstemmed | Phrenic nerve stimulation to treat patients with central sleep apnoea and heart failure |
title_short | Phrenic nerve stimulation to treat patients with central sleep apnoea and heart failure |
title_sort | phrenic nerve stimulation to treat patients with central sleep apnoea and heart failure |
topic | New Devices |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607512/ https://www.ncbi.nlm.nih.gov/pubmed/30303611 http://dx.doi.org/10.1002/ejhf.1312 |
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