Cargando…

Dystrophin R16/17 protein therapy restores sarcolemmal nNOS in trans and improves muscle perfusion and function

BACKGROUND: Delocalization of neuronal nitric oxide synthase (nNOS) from the sarcolemma leads to functional muscle ischemia. This contributes to the pathogenesis in cachexia, aging and muscular dystrophy. Mutations in the gene encoding dystrophin result in Duchenne muscular dystrophy (DMD) and Becke...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Junling, Yang, Hsiao Tung, Wasala, Lakmini, Zhang, Keqing, Yue, Yongping, Duan, Dongsheng, Lai, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607532/ https://www.ncbi.nlm.nih.gov/pubmed/31266455 http://dx.doi.org/10.1186/s10020-019-0101-6

Ejemplares similares

Dystrophin R16/17-syntrophin PDZ fusion protein restores sarcolemmal nNOSμ
por: Patel, Aman, et al.
Publicado: (2018)

A Hypothesis for Examining Skeletal Muscle Biopsy-Derived Sarcolemmal nNOSμ as Surrogate for Enteric nNOSα Function
por: Chaudhury, Arun
Publicado: (2015)

Commentary: A Hypothesis for Examining Skeletal Muscle Biopsy-Derived Sarcolemmal nNOSμ as Surrogate for Enteric nNOSα Function
por: Percival, Justin
Publicado: (2015)

In vivo requirement of the α-syntrophin PDZ domain for the sarcolemmal localization of nNOS and aquaporin-4
por: Adams, Marvin E., et al.
Publicado: (2001)

Fatigue and Muscle Atrophy in a Mouse Model of Myasthenia Gravis Is Paralleled by Loss of Sarcolemmal nNOS
por: Meinen, Sarina, et al.
Publicado: (2012)

High-Resolution Histological Landscape of AAV DNA Distribution in Cellular Compartments and Tissues following Local and Systemic Injection
por: Zhao, Junling, et al.
Publicado: (2020)

Micro-dystrophin AAV Vectors Made by Transient Transfection and Herpesvirus System Are Equally Potent in Treating mdx Mouse Muscle Disease
por: Hakim, Chady H., et al.
Publicado: (2020)

Response: “Commentary: A Hypothesis for Examining Skeletal Muscle Biopsy-Derived Sarcolemmal nNOSµ as Surrogate for Enteric nNOSα Function”. nNOS(skeletal muscle) may be Evidentiary for Enteric NO-Transmission Despite nNOSµ/α Differences
por: Chaudhury, Arun
Publicado: (2016)

Functional Deficits in nNOSμ-Deficient Skeletal Muscle: Myopathy in nNOS Knockout Mice
por: Percival, Justin M., et al.
Publicado: (2008)

Voltage-Dependent Sarcolemmal Ion Channel Abnormalities in the Dystrophin-Deficient Heart
por: Koenig, Xaver, et al.
Publicado: (2018)

The FVB Background Does Not Dramatically Alter the Dystrophic Phenotype of Mdx Mice
por: Wasala, Nalinda B., et al.
Publicado: (2015)

100-fold but not 50-fold dystrophin overexpression aggravates electrocardiographic defects in the mdx model of Duchenne muscular dystrophy
por: Yue, Yongping, et al.
Publicado: (2016)

Neuronal Nitric Oxide Synthase-Rescue of Dystrophin/Utrophin Double Knockout Mice does not Require nNOS Localization to the Cell Membrane
por: Wehling-Henricks, Michelle, et al.
Publicado: (2011)

Mechanisms of NOS1AP action on NMDA receptor-nNOS signaling
por: Courtney, Michael J., et al.
Publicado: (2014)

Dual role of nNOS in ischemic injury and preconditioning
por: Barua, Anupama, et al.
Publicado: (2010)

Inhibition of the AMPK/nNOS pathway for neuroprotection in stroke
por: Khan, Mushfiquddin, et al.
Publicado: (2016)

Proteomic analysis identifies key differences in the cardiac interactomes of dystrophin and micro-dystrophin
por: Wang, Hong, et al.
Publicado: (2021)

Loss of sarcolemmal dystrophin and dystroglycan may be a potential mechanism for myocardial dysfunction in severe sepsis
por: Celes, MRN, et al.
Publicado: (2009)

Perspective: Spectrin-Like Repeats in Dystrophin Have Unique Binding Preferences for Syntrophin Adaptors That Explain the Mystery of How nNOSμ Localizes to the Sarcolemma
por: Percival, Justin M.
Publicado: (2018)

Characteristics of colonic migrating motor complexes in neuronal NOS (nNOS) knockout mice
por: Spencer, Nick J.
Publicado: (2013)

cAMP/PKA Agonist Restores the Fasting-Induced Down-Regulation of nNOS Expression in the Paraventricular Nucleus
por: Yoo, Sang Bae, et al.
Publicado: (2012)

Disruption of sarcolemmal dystrophin and β-dystroglycan may be a potential mechanism for myocardial dysfunction in severe sepsis
por: Celes, MR, et al.
Publicado: (2010)

Uniform sarcolemmal dystrophin expression is required to prevent extracellular microRNA release and improve dystrophic pathology
por: van Westering, Tirsa L.E., et al.
Publicado: (2019)

Supplementation of 17β-Estradiol Normalizes Rapid Gastric Emptying by Restoring Impaired Nrf2 and nNOS Function in Obesity-Induced Diabetic Ovariectomized Mice
por: Sprouse, Jeremy C., et al.
Publicado: (2020)

Transplanted ENSCs form functional connections with intestinal smooth muscle and restore colonic motility in nNOS-deficient mice
por: Hotta, Ryo, et al.
Publicado: (2023)

nNOS/GSNOR interaction contributes to skeletal muscle differentiation and homeostasis
por: Montagna, Costanza, et al.
Publicado: (2019)

Novel long-range inhibitory nNOS-expressing hippocampal cells
por: Christenson Wick, Zoé, et al.
Publicado: (2019)

Acupuncture Attenuates Blood Pressure via Inducing the Expression of nNOS
por: Wang, Lu, et al.
Publicado: (2021)

nNOS and Neurological, Neuropsychiatric Disorders: A 20-Year Story
por: Zhu, Li-Juan, et al.
Publicado: (2023)

17β-Estradiol Suppresses Gastric Inflammatory and Apoptotic Stress Responses and Restores nNOS-Mediated Gastric Emptying in Streptozotocin (STZ)-Induced Diabetic Female Mice
por: Sprouse, Jeremy, et al.
Publicado: (2023)

A Five-Repeat Micro-Dystrophin Gene Ameliorated Dystrophic Phenotype in the Severe DBA/2J-mdx Model of Duchenne Muscular Dystrophy
por: Hakim, Chady H., et al.
Publicado: (2017)

Marginal Level Dystrophin Expression Improves Clinical Outcome in a Strain of Dystrophin/Utrophin Double Knockout Mice
por: Li, Dejia, et al.
Publicado: (2010)

Rational engineering of a functional CpG-free ITR for AAV gene therapy
por: Pan, Xiufang, et al.
Publicado: (2022)

nNOS and Nox4 go nuclear: nNOS-derived and NADPH oxidase-derived reactive oxygen/nitrogen species promote oxidative nuclear damage in alveolar epithelial cells
por: Connelly, R, et al.
Publicado: (2007)

GRAF1 deficiency blunts sarcolemmal injury repair and exacerbates cardiac and skeletal muscle pathology in dystrophin-deficient mice
por: Lenhart, Kaitlin C., et al.
Publicado: (2015)

Sarcolemma-localized nNOS is required to maintain activity after mild exercise
por: Kobayashi, Yvonne M., et al.
Publicado: (2008)

Cannabinoid Regulation of Nitric Oxide Synthase I (nNOS) in Neuronal Cells
por: Carney, Skyla T., et al.
Publicado: (2009)

Evidence of nNOS and ChAT positive phenotypes in nervous ganglia of the retrostyloid space
por: Andrei, F, et al.
Publicado: (2012)

Targeting nNOS ameliorates the severe neuropathic pain due to chronic pancreatitis
por: Demir, Ihsan Ekin, et al.
Publicado: (2019)

A Novel Prodrug of a nNOS Inhibitor with Improved Pharmacokinetic Potential
por: Maccallini, Cristina, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_6o701cirv7krtk6fcji5hpojhf