Disruption of vacuolar protein sorting components of the HOPS complex leads to enhanced secretion of recombinant proteins in Pichia pastoris

BACKGROUND: The yeast Pichia pastoris is a widely used host for the secretion of heterologous proteins. Despite being an efficient producer, we observed previously that certain recombinant proteins were mistargeted to the vacuole on their route to secretion. Simultaneous disruption of one vacuolar s...

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Detalles Bibliográficos
Autores principales: Marsalek, Lukas, Puxbaum, Verena, Buchetics, Markus, Mattanovich, Diethard, Gasser, Brigitte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607557/
https://www.ncbi.nlm.nih.gov/pubmed/31269943
http://dx.doi.org/10.1186/s12934-019-1155-4

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