An experimental model of Braak’s pretangle proposal for the origin of Alzheimer’s disease: the role of locus coeruleus in early symptom development

BACKGROUND: The earliest brain pathology related to Alzheimer’s disease (AD) is hyperphosphorylated soluble tau in the noradrenergic locus coeruleus (LC) neurons. Braak characterizes five pretangle tau stages preceding AD tangles. Pretangles begin in young humans and persist in the LC while spreadin...

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Detalles Bibliográficos
Autores principales: Ghosh, Abhinaba, Torraville, Sarah E., Mukherjee, Bandhan, Walling, Susan G., Martin, Gerard M., Harley, Carolyn W., Yuan, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607586/
https://www.ncbi.nlm.nih.gov/pubmed/31266535
http://dx.doi.org/10.1186/s13195-019-0511-2

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