Identification of Germline Mismatch Repair Gene Mutations in Lung Cancer Patients With Paired Tumor-Normal Next Generation Sequencing: A Retrospective Study

Background: Paired tumor-normal targeted next-generation sequencing (NGS) is primarily used to identify actionable somatic mutations, but can also detect germline variants including pathogenic germline mutations in DNA mismatch repair (MMR) genes that underlie Lynch syndrome. In the present study we...

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Detalles Bibliográficos
Autores principales: Sun, Sibo, Liu, Yiqian, Eisfeld, Ann-Kathrin, Zhen, Fuxi, Jin, Shidai, Gao, Wen, Yu, Tongfu, Chen, Liang, Wang, Wei, Chen, Wei, Yuan, Mingming, Chen, Rongrong, He, Kai, Guo, Renhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607931/
https://www.ncbi.nlm.nih.gov/pubmed/31297337
http://dx.doi.org/10.3389/fonc.2019.00550

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