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Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation

Humans are adept in simultaneously following multiple goals, but the neural mechanisms for maintaining specific goals and distinguishing them from other goals are incompletely understood. For short time scales, working memory studies suggest that multiple mental contents are maintained by theta-coup...

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Autores principales: Kunz, Lukas, Wang, Liang, Lachner-Piza, Daniel, Zhang, Hui, Brandt, Armin, Dümpelmann, Matthias, Reinacher, Peter C., Coenen, Volker A., Chen, Dong, Wang, Wen-Xu, Zhou, Wenjing, Liang, Shuli, Grewe, Philip, Bien, Christian G., Bierbrauer, Anne, Navarro Schröder, Tobias, Schulze-Bonhage, Andreas, Axmacher, Nikolai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609163/
https://www.ncbi.nlm.nih.gov/pubmed/31281882
http://dx.doi.org/10.1126/sciadv.aav8192
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author Kunz, Lukas
Wang, Liang
Lachner-Piza, Daniel
Zhang, Hui
Brandt, Armin
Dümpelmann, Matthias
Reinacher, Peter C.
Coenen, Volker A.
Chen, Dong
Wang, Wen-Xu
Zhou, Wenjing
Liang, Shuli
Grewe, Philip
Bien, Christian G.
Bierbrauer, Anne
Navarro Schröder, Tobias
Schulze-Bonhage, Andreas
Axmacher, Nikolai
author_facet Kunz, Lukas
Wang, Liang
Lachner-Piza, Daniel
Zhang, Hui
Brandt, Armin
Dümpelmann, Matthias
Reinacher, Peter C.
Coenen, Volker A.
Chen, Dong
Wang, Wen-Xu
Zhou, Wenjing
Liang, Shuli
Grewe, Philip
Bien, Christian G.
Bierbrauer, Anne
Navarro Schröder, Tobias
Schulze-Bonhage, Andreas
Axmacher, Nikolai
author_sort Kunz, Lukas
collection PubMed
description Humans are adept in simultaneously following multiple goals, but the neural mechanisms for maintaining specific goals and distinguishing them from other goals are incompletely understood. For short time scales, working memory studies suggest that multiple mental contents are maintained by theta-coupled reactivation, but evidence for similar mechanisms during complex behaviors such as goal-directed navigation is scarce. We examined intracranial electroencephalography recordings of epilepsy patients performing an object-location memory task in a virtual environment. We report that large-scale electrophysiological representations of objects that cue for specific goal locations are dynamically reactivated during goal-directed navigation. Reactivation of different cue representations occurred at stimulus-specific hippocampal theta phases. Locking to more distinct theta phases predicted better memory performance, identifying hippocampal theta phase coding as a mechanism for separating competing goals. Our findings suggest shared neural mechanisms between working memory and goal-directed navigation and provide new insights into the functions of the hippocampal theta rhythm.
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spelling pubmed-66091632019-07-05 Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation Kunz, Lukas Wang, Liang Lachner-Piza, Daniel Zhang, Hui Brandt, Armin Dümpelmann, Matthias Reinacher, Peter C. Coenen, Volker A. Chen, Dong Wang, Wen-Xu Zhou, Wenjing Liang, Shuli Grewe, Philip Bien, Christian G. Bierbrauer, Anne Navarro Schröder, Tobias Schulze-Bonhage, Andreas Axmacher, Nikolai Sci Adv Research Articles Humans are adept in simultaneously following multiple goals, but the neural mechanisms for maintaining specific goals and distinguishing them from other goals are incompletely understood. For short time scales, working memory studies suggest that multiple mental contents are maintained by theta-coupled reactivation, but evidence for similar mechanisms during complex behaviors such as goal-directed navigation is scarce. We examined intracranial electroencephalography recordings of epilepsy patients performing an object-location memory task in a virtual environment. We report that large-scale electrophysiological representations of objects that cue for specific goal locations are dynamically reactivated during goal-directed navigation. Reactivation of different cue representations occurred at stimulus-specific hippocampal theta phases. Locking to more distinct theta phases predicted better memory performance, identifying hippocampal theta phase coding as a mechanism for separating competing goals. Our findings suggest shared neural mechanisms between working memory and goal-directed navigation and provide new insights into the functions of the hippocampal theta rhythm. American Association for the Advancement of Science 2019-07-03 /pmc/articles/PMC6609163/ /pubmed/31281882 http://dx.doi.org/10.1126/sciadv.aav8192 Text en Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Kunz, Lukas
Wang, Liang
Lachner-Piza, Daniel
Zhang, Hui
Brandt, Armin
Dümpelmann, Matthias
Reinacher, Peter C.
Coenen, Volker A.
Chen, Dong
Wang, Wen-Xu
Zhou, Wenjing
Liang, Shuli
Grewe, Philip
Bien, Christian G.
Bierbrauer, Anne
Navarro Schröder, Tobias
Schulze-Bonhage, Andreas
Axmacher, Nikolai
Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation
title Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation
title_full Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation
title_fullStr Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation
title_full_unstemmed Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation
title_short Hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation
title_sort hippocampal theta phases organize the reactivation of large-scale electrophysiological representations during goal-directed navigation
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609163/
https://www.ncbi.nlm.nih.gov/pubmed/31281882
http://dx.doi.org/10.1126/sciadv.aav8192
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