Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation

The decrease in incretin effects is an important etiologic component of type 2 diabetes with unknown mechanisms. In an attempt to understand obesity-induced changes in liver oxygen homeostasis, we found that liver HIF-1α expression was increased mainly by soluble factors released from obese adipocyt...

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Detalles Bibliográficos
Autores principales: Lee, Yun Sok, Riopel, Matthew, Cabrales, Pedro, Bandyopadhyay, Guatam K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609217/
https://www.ncbi.nlm.nih.gov/pubmed/31281892
http://dx.doi.org/10.1126/sciadv.aaw4176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609217/
https://www.ncbi.nlm.nih.gov/pubmed/31281892
http://dx.doi.org/10.1126/sciadv.aaw4176

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