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High-speed AFM reveals accelerated binding of agitoxin-2 to a K(+) channel by induced fit
Agitoxin-2 (AgTx2) from scorpion venom is a potent blocker of K(+) channels. The docking model has been elucidated, but it remains unclear whether binding dynamics are described by a two-state model (AgTx2-bound and AgTx2-unbound) or a more complicated mechanism, such as induced fit or conformationa...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609221/ https://www.ncbi.nlm.nih.gov/pubmed/31281899 http://dx.doi.org/10.1126/sciadv.aax0495 |