Identification of Mutations in the mrdA Gene Encoding PBP2 That Reduce Carbapenem and Diazabicyclooctane Susceptibility of Escherichia coli Clinical Isolates with Mutations in ftsI (PBP3) and Which Carry bla(NDM-1)

Penicillin-binding proteins (PBPs) are essential for bacterial cell wall biosynthesis, and several are clinically validated antibacterial targets of β-lactam antibiotics. We identified mutations in the mrdA gene encoding the PBP2 protein in two Escherichia coli bla(NDM-1) clinical isolates that redu...

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Detalles Bibliográficos
Autores principales: Ranjitkar, Srijan, Reck, Folkert, Ke, Xiaobo, Zhu, Qingming, McEnroe, Glenn, Lopez, Sara L., Dean, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Observation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609223/
https://www.ncbi.nlm.nih.gov/pubmed/31270174
http://dx.doi.org/10.1128/mSphere.00074-19

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