Cargando…
Anti-Factor H Antibody Reactivity in Young Adults Vaccinated with a Meningococcal Serogroup B Vaccine Containing Factor H Binding Protein
Meningococcal serogroup B (MenB) vaccines contain recombinant factor H binding protein (FHbp), which can complex with complement factor H (CFH) and thereby risk eliciting anti-FH autoantibodies. While anti-FH antibodies can be present in sera of healthy persons, the antibodies are implicated in auto...
Autores principales: | Sharkey, Kelsey, Beernink, Peter T., Langley, Joanne M., Gantt, Soren, Quach, Caroline, Dold, Christina, Liu, Qin, Galvan, Manuel, Granoff, Dan M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609231/ https://www.ncbi.nlm.nih.gov/pubmed/31270173 http://dx.doi.org/10.1128/mSphere.00393-19 |
Ejemplares similares
-
Two human antibodies to a meningococcal serogroup B vaccine antigen enhance binding of complement Factor H by stabilizing the Factor H binding site
por: Sands, Nathaniel A., et al.
Publicado: (2021) -
The Effect of Human Factor H on Immunogenicity of Meningococcal Native Outer Membrane Vesicle Vaccines with Over-Expressed Factor H Binding Protein
por: Beernink, Peter T., et al.
Publicado: (2012) -
A Newly-Identified Polymorphism in Rhesus Macaque Complement Factor H Modulates Binding Affinity for Meningococcal FHbp
por: Konar, Monica, et al.
Publicado: (2015) -
Functional Analysis of the Human Antibody Response to Meningococcal Factor H Binding Protein
por: Beernink, Peter T., et al.
Publicado: (2015) -
Monoclonal Antibodies to Meningococcal Factor H Binding Protein with Overlapping Epitopes and Discordant Functional Activity
por: Giuntini, Serena, et al.
Publicado: (2012)