Cargando…

Constructing personalized longitudinal holo’omes of colon cancer-prone humans and their modeling in flies and mice

Specific host genes and intestinal microbes, dysbiosis, aberrant immune responses and lifestyle may contribute to intestinal inflammation and cancer, but each of these parameters does not suffice to explain why sporadic colon cancer develops at an old age and only in some of the people with the same...

Descripción completa

Detalles Bibliográficos
Autores principales: Panagi, Myrofora, Georgila, Konstantina, Eliopoulos, Aristides G., Apidianakis, Yiorgos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609240/
https://www.ncbi.nlm.nih.gov/pubmed/31289620
http://dx.doi.org/10.18632/oncotarget.6463
_version_ 1783432277136506880
author Panagi, Myrofora
Georgila, Konstantina
Eliopoulos, Aristides G.
Apidianakis, Yiorgos
author_facet Panagi, Myrofora
Georgila, Konstantina
Eliopoulos, Aristides G.
Apidianakis, Yiorgos
author_sort Panagi, Myrofora
collection PubMed
description Specific host genes and intestinal microbes, dysbiosis, aberrant immune responses and lifestyle may contribute to intestinal inflammation and cancer, but each of these parameters does not suffice to explain why sporadic colon cancer develops at an old age and only in some of the people with the same profile. To improve our understanding, longitudinal multi-omic and personalized studies will help to pinpoint combinations of host genetic, epigenetic, microbiota and lifestyle-shaped factors, such as blood factors and metabolites that change as we age. The intestinal holo’ome – defined as the combination of host and microbiota genomes, transcriptomes, proteomes, and metabolomes – may be imbalanced and shift to disease when the wrong host gene expression profile meets the wrong microbiota composition. These imbalances can be triggered by the dietary- or lifestyle-shaped intestinal environment. Accordingly, personalized human intestinal holo’omes will differ significantly among individuals and between two critical points in time: long before and upon the onset of disease. Detrimental combinations of factors could therefore be pinpointed computationally and validated using animal models, such as mice and flies. Finally, treatment strategies that break these harmful combinations could be tested in clinical trials. Herein we provide an overview of the literature and a roadmap to this end.
format Online
Article
Text
id pubmed-6609240
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Impact Journals LLC
record_format MEDLINE/PubMed
spelling pubmed-66092402019-07-09 Constructing personalized longitudinal holo’omes of colon cancer-prone humans and their modeling in flies and mice Panagi, Myrofora Georgila, Konstantina Eliopoulos, Aristides G. Apidianakis, Yiorgos Oncotarget Review Specific host genes and intestinal microbes, dysbiosis, aberrant immune responses and lifestyle may contribute to intestinal inflammation and cancer, but each of these parameters does not suffice to explain why sporadic colon cancer develops at an old age and only in some of the people with the same profile. To improve our understanding, longitudinal multi-omic and personalized studies will help to pinpoint combinations of host genetic, epigenetic, microbiota and lifestyle-shaped factors, such as blood factors and metabolites that change as we age. The intestinal holo’ome – defined as the combination of host and microbiota genomes, transcriptomes, proteomes, and metabolomes – may be imbalanced and shift to disease when the wrong host gene expression profile meets the wrong microbiota composition. These imbalances can be triggered by the dietary- or lifestyle-shaped intestinal environment. Accordingly, personalized human intestinal holo’omes will differ significantly among individuals and between two critical points in time: long before and upon the onset of disease. Detrimental combinations of factors could therefore be pinpointed computationally and validated using animal models, such as mice and flies. Finally, treatment strategies that break these harmful combinations could be tested in clinical trials. Herein we provide an overview of the literature and a roadmap to this end. Impact Journals LLC 2015-12-04 /pmc/articles/PMC6609240/ /pubmed/31289620 http://dx.doi.org/10.18632/oncotarget.6463 Text en Copyright: © 2019 Panagi et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Review
Panagi, Myrofora
Georgila, Konstantina
Eliopoulos, Aristides G.
Apidianakis, Yiorgos
Constructing personalized longitudinal holo’omes of colon cancer-prone humans and their modeling in flies and mice
title Constructing personalized longitudinal holo’omes of colon cancer-prone humans and their modeling in flies and mice
title_full Constructing personalized longitudinal holo’omes of colon cancer-prone humans and their modeling in flies and mice
title_fullStr Constructing personalized longitudinal holo’omes of colon cancer-prone humans and their modeling in flies and mice
title_full_unstemmed Constructing personalized longitudinal holo’omes of colon cancer-prone humans and their modeling in flies and mice
title_short Constructing personalized longitudinal holo’omes of colon cancer-prone humans and their modeling in flies and mice
title_sort constructing personalized longitudinal holo’omes of colon cancer-prone humans and their modeling in flies and mice
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609240/
https://www.ncbi.nlm.nih.gov/pubmed/31289620
http://dx.doi.org/10.18632/oncotarget.6463
work_keys_str_mv AT panagimyrofora constructingpersonalizedlongitudinalholoomesofcoloncancerpronehumansandtheirmodelinginfliesandmice
AT georgilakonstantina constructingpersonalizedlongitudinalholoomesofcoloncancerpronehumansandtheirmodelinginfliesandmice
AT eliopoulosaristidesg constructingpersonalizedlongitudinalholoomesofcoloncancerpronehumansandtheirmodelinginfliesandmice
AT apidianakisyiorgos constructingpersonalizedlongitudinalholoomesofcoloncancerpronehumansandtheirmodelinginfliesandmice