Cargando…

Essential metabolism for a minimal cell

JCVI-syn3A, a robust minimal cell with a 543 kbp genome and 493 genes, provides a versatile platform to study the basics of life. Using the vast amount of experimental information available on its precursor, Mycoplasma mycoides capri, we assembled a near-complete metabolic network with 98% of enzyma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Breuer, Marian, Earnest, Tyler M, Merryman, Chuck, Wise, Kim S, Sun, Lijie, Lynott, Michaela R, Hutchison, Clyde A, Smith, Hamilton O, Lapek, John D, Gonzalez, David J, de Crécy-Lagard, Valérie, Haas, Drago, Hanson, Andrew D, Labhsetwar, Piyush, Glass, John I, Luthey-Schulten, Zaida
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Computational and Systems Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609329/ https://www.ncbi.nlm.nih.gov/pubmed/30657448 http://dx.doi.org/10.7554/eLife.36842

Ejemplares similares

Population FBA predicts metabolic phenotypes in yeast
por: Labhsetwar, Piyush, et al.
Publicado: (2017)

Toward the Complete Functional Characterization of a Minimal Bacterial Proteome
por: Bianchi, David M., et al.
Publicado: (2022)

Free-energy simulations reveal molecular mechanism for functional switch of a DNA helicase
por: Ma, Wen, et al.
Publicado: (2018)

Metabolite Damage and Damage Control in a Minimal Genome
por: Haas, Drago, et al.
Publicado: (2022)

Polar Effects of Transposon Insertion into a Minimal Bacterial Genome
por: Hutchison, Clyde A., et al.
Publicado: (2019)

Kinetic Modeling of the Genetic Information Processes in a Minimal Cell
por: Thornburg, Zane R., et al.
Publicado: (2019)

Towards a Computational Model of a Methane Producing Archaeum
por: Peterson, Joseph R., et al.
Publicado: (2014)

Fundamental behaviors emerge from simulations of a living minimal cell
por: Thornburg, Zane R., et al.
Publicado: (2022)

Effects of individual base-pairs on in vivo target search and destruction kinetics of bacterial small RNA
por: Poddar, Anustup, et al.
Publicado: (2021)

Hybrid CME–ODE method for efficient simulation of the galactose switch in yeast
por: Bianchi, David M., et al.
Publicado: (2018)

MultiSeq: unifying sequence and structure data for evolutionary analysis
por: Roberts, Elijah, et al.
Publicado: (2006)

Correction: Parametric studies of metabolic cooperativity in Escherichia coli colonies: Strain and geometric confinement effects
por: Peterson, Joseph R., et al.
Publicado: (2017)

Parametric studies of metabolic cooperativity in Escherichia coli colonies: Strain and geometric confinement effects
por: Peterson, Joseph R., et al.
Publicado: (2017)

Spatially-resolved metabolic cooperativity within dense bacterial colonies
por: Cole, John A, et al.
Publicado: (2015)

Horizontal gene transfer of zinc and non-zinc forms of bacterial ribosomal protein S4
por: Chen, Ke, et al.
Publicado: (2009)

Genome-Scale Metabolic Modeling of Archaea Lends Insight into Diversity of Metabolic Function
por: Thor, ShengShee, et al.
Publicado: (2017)

Gross Chromosomal Rearrangements in Kluyveromyces marxianus Revealed by Illumina and Oxford Nanopore Sequencing
por: Ding, Lin, et al.
Publicado: (2020)

An in-silico human cell model reveals the influence of spatial organization on RNA splicing
por: Ghaemi, Zhaleh, et al.
Publicado: (2020)

In Situ Conformational Changes of the Escherichia coli Serine Chemoreceptor in Different Signaling States
por: Yang, Wen, et al.
Publicado: (2019)

Generating Chromosome Geometries in a Minimal Cell From Cryo-Electron Tomograms and Chromosome Conformation Capture Maps
por: Gilbert, Benjamin R., et al.
Publicado: (2021)

Noise Contributions in an Inducible Genetic Switch: A Whole-Cell Simulation Study
por: Roberts, Elijah, et al.
Publicado: (2011)

Variations in metabolic pathways create challenges for automated metabolic reconstructions: Examples from the tetrahydrofolate synthesis pathway
por: de Crécy-Lagard, Valérie
Publicado: (2014)

Rescue of mutant fitness defects using in vitro reconstituted designer transposons in Mycoplasma mycoides
por: Karas, Bogumil J., et al.
Publicado: (2014)

One step engineering of the small-subunit ribosomal RNA using CRISPR/Cas9
por: Kannan, Krishna, et al.
Publicado: (2016)

Containerization as a means of extending the lifetime of HDL development tools
por: Laforge, Clyde
Publicado: (2023)

Paying off technical debt of SoC code-bases through standards and good practices
por: Laforge, Clyde
Publicado: (2022)

Predicting the pathway involved in post-translational modification of Elongation factor P in a subset of bacterial species
por: Bailly, Marc, et al.
Publicado: (2010)

The emerging role of complex modifications of tRNA(Lys)(UUU) in signaling pathways
por: Thiaville, Patrick C., et al.
Publicado: (2015)

Pyridoxal 5’-phosphate synthesis and salvage in Bacteria and Archaea: predicting pathway variant distributions and holes
por: Denise, Rémi, et al.
Publicado: (2023)

Kinetic and structural mechanism for DNA unwinding by a non-hexameric helicase
por: Carney, Sean P., et al.
Publicado: (2021)

Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations
por: de Crécy-Lagard, Valérie, et al.
Publicado: (2007)

The Escherichia coli COG1738 Member YhhQ Is Involved in 7-Cyanodeazaguanine (preQ(0)) Transport
por: Zallot, Rémi, et al.
Publicado: (2017)

Structure and dynamics of the E. coli chemotaxis core signaling complex by cryo-electron tomography and molecular simulations
por: Cassidy, C. Keith, et al.
Publicado: (2020)

Genome-wide gene expression and RNA half-life measurements allow predictions of regulation and metabolic behavior in Methanosarcina acetivorans
por: Peterson, Joseph R., et al.
Publicado: (2016)

Stochastic Analysis Demonstrates the Dual Role of Hfq in Chaperoning E. coli Sugar Shock Response
por: Bianchi, David M., et al.
Publicado: (2020)

Deazaguanine derivatives, examples of crosstalk between RNA and DNA modification pathways
por: Hutinet, Geoffrey, et al.
Publicado: (2016)

Comparative Genomic Analysis of the DUF34 Protein Family Suggests Role as a Metal Ion Chaperone or Insertase
por: Reed, Colbie J., et al.
Publicado: (2021)

Simultaneous non-contiguous deletions using large synthetic DNA and site-specific recombinases
por: Krishnakumar, Radha, et al.
Publicado: (2014)

Dynamics of chromosome organization in a minimal bacterial cell
por: Gilbert, Benjamin R., et al.
Publicado: (2023)

Protein-guided RNA dynamics during early ribosome assembly
por: Kim, Hajin, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_j1npcphl2o1b5kak3skuue3sco