Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments

Most human tumors are heterogeneous, composed of cellular clones with different properties present at variable frequencies. Highly heterogeneous tumors have poor clinical outcomes, yet the underlying mechanism remains poorly understood. Here, we show that minor subclones of breast cancer cells expre...

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Detalles Bibliográficos
Autores principales: Janiszewska, Michalina, Tabassum, Doris P., Castaño, Zafira, Cristea, Simona, Yamamoto, Kimiyo N., Kingston, Natalie L., Murphy, Katherine C., Shu, Shaokun, Harper, Nicholas W., Del Alcazar, Carlos Gil, Alečković, Maša, Ekram, Muhammad B., Cohen, Ofir, Kwak, Minsuk, Qin, Yuanbo, Laszewski, Tyler, Luoma, Adrienne, Marusyk, Andriy, Wucherpfennig, Kai W., Wagle, Nikhil, Fan, Rong, Michor, Franziska, McAllister, Sandra S., Polyak, Kornelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609451/
https://www.ncbi.nlm.nih.gov/pubmed/31263265
http://dx.doi.org/10.1038/s41556-019-0346-x

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