Histidine at position 462 determines the low quinine sensitivity of ether‐à‐go‐go channel superfamily member K(v)12.1

BACKGROUND AND PURPOSE: The ether‐à‐go‐go (Eag) K(v) superfamily comprises closely related K(v)10, K(v)11, and K(v)12 subunits. K(v)11.1 (termed hERG in humans) gained much attention, as drug‐induced inhibition of these channels is a frequent cause of sudden death in humans. The exclusive drug sensi...

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Detalles Bibliográficos
Autores principales: Dierich, Marlen, van Ham, Willem B., Stary‐Weinzinger, Anna, Leitner, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609544/
https://www.ncbi.nlm.nih.gov/pubmed/31032878
http://dx.doi.org/10.1111/bph.14693

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609544/
https://www.ncbi.nlm.nih.gov/pubmed/31032878
http://dx.doi.org/10.1111/bph.14693

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