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POISED-5, a portable on-board electrochemical impedance spectroscopy biomarker analysis device

Point-of-care medical devices offer the potential for rapid biomarker detection and reporting of medical conditions, thereby bypassing the requirements for offline clinical laboratory facilities in many cases. Label-free electrochemical techniques are suitable for use in handheld diagnostic devices...

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Detalles Bibliográficos
Autores principales: Sawhney, M. Anne, Conlan, R. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609592/
https://www.ncbi.nlm.nih.gov/pubmed/31273464
http://dx.doi.org/10.1007/s10544-019-0406-9
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author Sawhney, M. Anne
Conlan, R. S.
author_facet Sawhney, M. Anne
Conlan, R. S.
author_sort Sawhney, M. Anne
collection PubMed
description Point-of-care medical devices offer the potential for rapid biomarker detection and reporting of medical conditions, thereby bypassing the requirements for offline clinical laboratory facilities in many cases. Label-free electrochemical techniques are suitable for use in handheld diagnostic devices due the inherent electronic detection modality and low requirement for processing reagents. While electrochemical impedance sensing is widely used in tissue analysis such as body composition measurement, its use in point-of-care patient testing is yet to be widely adopted. Here we have considered a number of issues currently limiting the translation of electrochemical impedance sensing into clinical biosensor devices. Specifically, we have addressed the current requirement for these sensors to be connected to an external processor by applying a minimum number of frequencies required for optimized biomarker detection, and subsequently delivering analytics within the measurement device. The POISED-5 device was evaluated using a sensor for the ovarian cancer biomarker cancer antigen 125 (CA125), demonstrating performance comparable to standard laboratory equipment, with direct interpretation of response signal amplitude substituting traditional impedance component calculation and model fitting.
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spelling pubmed-66095922019-07-19 POISED-5, a portable on-board electrochemical impedance spectroscopy biomarker analysis device Sawhney, M. Anne Conlan, R. S. Biomed Microdevices Article Point-of-care medical devices offer the potential for rapid biomarker detection and reporting of medical conditions, thereby bypassing the requirements for offline clinical laboratory facilities in many cases. Label-free electrochemical techniques are suitable for use in handheld diagnostic devices due the inherent electronic detection modality and low requirement for processing reagents. While electrochemical impedance sensing is widely used in tissue analysis such as body composition measurement, its use in point-of-care patient testing is yet to be widely adopted. Here we have considered a number of issues currently limiting the translation of electrochemical impedance sensing into clinical biosensor devices. Specifically, we have addressed the current requirement for these sensors to be connected to an external processor by applying a minimum number of frequencies required for optimized biomarker detection, and subsequently delivering analytics within the measurement device. The POISED-5 device was evaluated using a sensor for the ovarian cancer biomarker cancer antigen 125 (CA125), demonstrating performance comparable to standard laboratory equipment, with direct interpretation of response signal amplitude substituting traditional impedance component calculation and model fitting. Springer US 2019-07-04 2019 /pmc/articles/PMC6609592/ /pubmed/31273464 http://dx.doi.org/10.1007/s10544-019-0406-9 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Sawhney, M. Anne
Conlan, R. S.
POISED-5, a portable on-board electrochemical impedance spectroscopy biomarker analysis device
title POISED-5, a portable on-board electrochemical impedance spectroscopy biomarker analysis device
title_full POISED-5, a portable on-board electrochemical impedance spectroscopy biomarker analysis device
title_fullStr POISED-5, a portable on-board electrochemical impedance spectroscopy biomarker analysis device
title_full_unstemmed POISED-5, a portable on-board electrochemical impedance spectroscopy biomarker analysis device
title_short POISED-5, a portable on-board electrochemical impedance spectroscopy biomarker analysis device
title_sort poised-5, a portable on-board electrochemical impedance spectroscopy biomarker analysis device
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609592/
https://www.ncbi.nlm.nih.gov/pubmed/31273464
http://dx.doi.org/10.1007/s10544-019-0406-9
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