A repository of protein abundance data of drug metabolizing enzymes and transporters for applications in physiologically based pharmacokinetic (PBPK) modelling and simulation

Population factors such as age, gender, ethnicity, genotype and disease state can cause inter-individual variability in pharmacokinetic (PK) profile of drugs. Primarily, this variability arises from differences in abundance of drug metabolizing enzymes and transporters (DMET) among individuals and/o...

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Detalles Bibliográficos
Autores principales: Ladumor, Mayur K., Thakur, Aarzoo, Sharma, Sheena, Rachapally, Aravind, Mishra, Sarang, Bobe, Priyanka, Rao, V. Kameswara, Pammi, Praneetha, Kangne, Hari, Levi, David, Balhara, Ankit, Ghandikota, Sriram, Joshi, Anupama, Nautiyal, Vivek, Prasad, Bhagwat, Singh, Saranjit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609630/
https://www.ncbi.nlm.nih.gov/pubmed/31273226
http://dx.doi.org/10.1038/s41598-019-45778-9

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