Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies

Persistent inflammation is a hallmark of many human diseases, including anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) and atherosclerosis. Here, we describe a dominant trigger of inflammation: human serum factor H-related protein FHR1. In vitro, this protein selectively binds to n...

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Detalles Bibliográficos
Autores principales: Irmscher, Sarah, Brix, Silke R., Zipfel, Svante L. H., Halder, Luke D., Mutlutürk, Sibel, Wulf, Sonia, Girdauskas, Evaldas, Reichenspurner, Hermann, Stahl, Rolf A. K., Jungnickel, Berit, Wiech, Thorsten, Zipfel, Peter F., Skerka, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609651/
https://www.ncbi.nlm.nih.gov/pubmed/31273197
http://dx.doi.org/10.1038/s41467-019-10766-0

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