Systemically administered peptain-1 inhibits retinal ganglion cell death in animal models: implications for neuroprotection in glaucoma

Axonal degeneration and death of retinal ganglion cells (RGCs) are the primary causes of vision loss in glaucoma. In this study, we evaluated the efficacy of a peptide (peptain-1) that exhibits robust chaperone and anti-apoptotic activities against RGC loss in two rodent models and in cultured RGCs....

Descripción completa

Detalles Bibliográficos
Autores principales: Stankowska, Dorota L., Nam, Mi-Hyun, Nahomi, Rooban B., Chaphalkar, Renuka M., Nandi, Sandip K., Fudala, Rafal, Krishnamoorthy, Raghu R., Nagaraj, Ram H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609721/
https://www.ncbi.nlm.nih.gov/pubmed/31285855
http://dx.doi.org/10.1038/s41420-019-0194-2

Ejemplares similares

Ejemplares similares