Simple 3D printed stainless steel microreactors for online mass spectrometric analysis

A simple flow chemistry microreactor with an electrospray ionization tip for real time mass spectrometric reaction monitoring is introduced. The microreactor was fabricated by a laser-based additive manufacturing technique from acid-resistant stainless steel 316L. The functionality of the microreact...

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Autores principales: Scotti, Gianmario, Nilsson, Sofia M.E., Matilainen, Ville-Pekka, Haapala, Markus, Boije af Gennäs, Gustav, Yli-Kauhaluoma, Jari, Salminen, Antti, Kotiaho, Tapio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609794/
https://www.ncbi.nlm.nih.gov/pubmed/31312730
http://dx.doi.org/10.1016/j.heliyon.2019.e02002
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author Scotti, Gianmario
Nilsson, Sofia M.E.
Matilainen, Ville-Pekka
Haapala, Markus
Boije af Gennäs, Gustav
Yli-Kauhaluoma, Jari
Salminen, Antti
Kotiaho, Tapio
author_facet Scotti, Gianmario
Nilsson, Sofia M.E.
Matilainen, Ville-Pekka
Haapala, Markus
Boije af Gennäs, Gustav
Yli-Kauhaluoma, Jari
Salminen, Antti
Kotiaho, Tapio
author_sort Scotti, Gianmario
collection PubMed
description A simple flow chemistry microreactor with an electrospray ionization tip for real time mass spectrometric reaction monitoring is introduced. The microreactor was fabricated by a laser-based additive manufacturing technique from acid-resistant stainless steel 316L. The functionality of the microreactor was investigated by using an inverse electron demand Diels-Alder and subsequent retro Diels-Alder reaction for testing. Challenges and problems encountered are discussed and improvements proposed. Adsorption of reagents to the rough stainless steel channel walls, short length of the reaction channel, and making a proper ESI tip present challenges, but the microreactor is potentially useful as a disposable device.
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spelling pubmed-66097942019-07-16 Simple 3D printed stainless steel microreactors for online mass spectrometric analysis Scotti, Gianmario Nilsson, Sofia M.E. Matilainen, Ville-Pekka Haapala, Markus Boije af Gennäs, Gustav Yli-Kauhaluoma, Jari Salminen, Antti Kotiaho, Tapio Heliyon Article A simple flow chemistry microreactor with an electrospray ionization tip for real time mass spectrometric reaction monitoring is introduced. The microreactor was fabricated by a laser-based additive manufacturing technique from acid-resistant stainless steel 316L. The functionality of the microreactor was investigated by using an inverse electron demand Diels-Alder and subsequent retro Diels-Alder reaction for testing. Challenges and problems encountered are discussed and improvements proposed. Adsorption of reagents to the rough stainless steel channel walls, short length of the reaction channel, and making a proper ESI tip present challenges, but the microreactor is potentially useful as a disposable device. Elsevier 2019-07-02 /pmc/articles/PMC6609794/ /pubmed/31312730 http://dx.doi.org/10.1016/j.heliyon.2019.e02002 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Scotti, Gianmario
Nilsson, Sofia M.E.
Matilainen, Ville-Pekka
Haapala, Markus
Boije af Gennäs, Gustav
Yli-Kauhaluoma, Jari
Salminen, Antti
Kotiaho, Tapio
Simple 3D printed stainless steel microreactors for online mass spectrometric analysis
title Simple 3D printed stainless steel microreactors for online mass spectrometric analysis
title_full Simple 3D printed stainless steel microreactors for online mass spectrometric analysis
title_fullStr Simple 3D printed stainless steel microreactors for online mass spectrometric analysis
title_full_unstemmed Simple 3D printed stainless steel microreactors for online mass spectrometric analysis
title_short Simple 3D printed stainless steel microreactors for online mass spectrometric analysis
title_sort simple 3d printed stainless steel microreactors for online mass spectrometric analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609794/
https://www.ncbi.nlm.nih.gov/pubmed/31312730
http://dx.doi.org/10.1016/j.heliyon.2019.e02002
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