High fluence PACK-CXL as adjuvant treatment for advanced Acanthamoeba keratitis

PURPOSE: To describe the outcome of adjuvant high fluence photoactivated chromophore for infectious keratitis cross-linking (PACK-CXL) used to treat an advanced form of refractory Acanthamoeba keratitis (AK) diagnosed several months after initial presentation. OBSERVATIONS: An otherwise healthy 24-y...

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Autores principales: Nateghi Pettersson, Mehrdad, Lagali, Neil, Mortensen, Jes, Jofré, Victor, Fagerholm, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609835/
https://www.ncbi.nlm.nih.gov/pubmed/31312750
http://dx.doi.org/10.1016/j.ajoc.2019.100499
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author Nateghi Pettersson, Mehrdad
Lagali, Neil
Mortensen, Jes
Jofré, Victor
Fagerholm, Per
author_facet Nateghi Pettersson, Mehrdad
Lagali, Neil
Mortensen, Jes
Jofré, Victor
Fagerholm, Per
author_sort Nateghi Pettersson, Mehrdad
collection PubMed
description PURPOSE: To describe the outcome of adjuvant high fluence photoactivated chromophore for infectious keratitis cross-linking (PACK-CXL) used to treat an advanced form of refractory Acanthamoeba keratitis (AK) diagnosed several months after initial presentation. OBSERVATIONS: An otherwise healthy 24-year old female presented with a severe unilateral keratitis. The diagnosis eluded clinicians for several months and when finally confirmed as AK, anti-amoebic therapy was instated and only appeared to be effective after addition of high fluence PACK-CXL. CONCLUSION AND IMPORTANCE: In this case of advanced AK, high fluence PACK-CXL treatment given adjuvant to pharmacologic anti-amoebic therapy resulted in lasting pain relief, re-epithelization and eradication of the Acanthamoeba parasite. Given adjuvant to anti-amoebic pharmacotherapy, high fluence PACK-CXL might be a useful method for treating typically refractory advanced AK.
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spelling pubmed-66098352019-07-16 High fluence PACK-CXL as adjuvant treatment for advanced Acanthamoeba keratitis Nateghi Pettersson, Mehrdad Lagali, Neil Mortensen, Jes Jofré, Victor Fagerholm, Per Am J Ophthalmol Case Rep Case Report PURPOSE: To describe the outcome of adjuvant high fluence photoactivated chromophore for infectious keratitis cross-linking (PACK-CXL) used to treat an advanced form of refractory Acanthamoeba keratitis (AK) diagnosed several months after initial presentation. OBSERVATIONS: An otherwise healthy 24-year old female presented with a severe unilateral keratitis. The diagnosis eluded clinicians for several months and when finally confirmed as AK, anti-amoebic therapy was instated and only appeared to be effective after addition of high fluence PACK-CXL. CONCLUSION AND IMPORTANCE: In this case of advanced AK, high fluence PACK-CXL treatment given adjuvant to pharmacologic anti-amoebic therapy resulted in lasting pain relief, re-epithelization and eradication of the Acanthamoeba parasite. Given adjuvant to anti-amoebic pharmacotherapy, high fluence PACK-CXL might be a useful method for treating typically refractory advanced AK. Elsevier 2019-06-20 /pmc/articles/PMC6609835/ /pubmed/31312750 http://dx.doi.org/10.1016/j.ajoc.2019.100499 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Nateghi Pettersson, Mehrdad
Lagali, Neil
Mortensen, Jes
Jofré, Victor
Fagerholm, Per
High fluence PACK-CXL as adjuvant treatment for advanced Acanthamoeba keratitis
title High fluence PACK-CXL as adjuvant treatment for advanced Acanthamoeba keratitis
title_full High fluence PACK-CXL as adjuvant treatment for advanced Acanthamoeba keratitis
title_fullStr High fluence PACK-CXL as adjuvant treatment for advanced Acanthamoeba keratitis
title_full_unstemmed High fluence PACK-CXL as adjuvant treatment for advanced Acanthamoeba keratitis
title_short High fluence PACK-CXL as adjuvant treatment for advanced Acanthamoeba keratitis
title_sort high fluence pack-cxl as adjuvant treatment for advanced acanthamoeba keratitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609835/
https://www.ncbi.nlm.nih.gov/pubmed/31312750
http://dx.doi.org/10.1016/j.ajoc.2019.100499
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