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Association between NAFLD and Risk of Colorectal Adenoma in Chinese Han Population

Background and Aims: Colorectal cancer is associated with non-alcoholic fatty liver disease (NAFLD) and other metabolic syndromes, such as obesity, abnormal blood glucose, and dyslipidemia. The relationship of NAFLD and colorectal adenoma, which is the precursor of colorectal cancer, is worthy of di...

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Autores principales: Li, Yuan, Liu, Shousheng, Gao, Yuqiang, Ma, Huan, Zhan, Shuhui, Yang, Yan, Xin, Yongning, Xuan, Shiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: XIA & HE Publishing Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609839/
https://www.ncbi.nlm.nih.gov/pubmed/31293908
http://dx.doi.org/10.14218/JCTH.2019.00010
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author Li, Yuan
Liu, Shousheng
Gao, Yuqiang
Ma, Huan
Zhan, Shuhui
Yang, Yan
Xin, Yongning
Xuan, Shiying
author_facet Li, Yuan
Liu, Shousheng
Gao, Yuqiang
Ma, Huan
Zhan, Shuhui
Yang, Yan
Xin, Yongning
Xuan, Shiying
author_sort Li, Yuan
collection PubMed
description Background and Aims: Colorectal cancer is associated with non-alcoholic fatty liver disease (NAFLD) and other metabolic syndromes, such as obesity, abnormal blood glucose, and dyslipidemia. The relationship of NAFLD and colorectal adenoma, which is the precursor of colorectal cancer, is worthy of discussion. The aim of this study was to investigate the association between colorectal adenoma and NAFLD, colorectal adenoma and metabolic syndrome in a Chinese Han population. Methods: This retrospective study analyzed the relationship between NAFLD and colorectal adenoma in 1089 patients in Qingdao municipal hospital. Subjects were divided into a colorectal adenoma group (n = 267) and a control group (n = 822). NAFLD and the controlled attenuation parameter (CAP) value were determined by abdominal ultrasound and FibroScan. Results: Patients with NAFLD in the colorectal adenoma group and the control group represented 142 cases (53.2%) and 360 cases (43.8%), respectively. The mean CAP value in the colorectal adenoma group was significantly higher than that in the control group. The values of body mass index, triglyceride, high-density lipoprotein cholesterol, aspartate aminotransferase, fasting plasma glucose, and uric acid were also significantly higher in the colorectal adenoma group than in the control group. Multifactor logistic regression analysis showed that the sex, NAFLD, CAP, body mass index, triglyceride, aspartate aminotransferase, and fasting plasma glucose were significant risk factors for colorectal adenoma. Besides, NAFLD and CAP value were significant risk factors for colorectal adenoma in males but not in females. Conclusions: NAFLD and metabolic syndrome were tightly associated with the risk of colorectal adenoma in this Chinese Han population. The effect of NAFLD on colorectal adenoma was prominent in males rather than in females.
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spelling pubmed-66098392019-07-10 Association between NAFLD and Risk of Colorectal Adenoma in Chinese Han Population Li, Yuan Liu, Shousheng Gao, Yuqiang Ma, Huan Zhan, Shuhui Yang, Yan Xin, Yongning Xuan, Shiying J Clin Transl Hepatol Original Article Background and Aims: Colorectal cancer is associated with non-alcoholic fatty liver disease (NAFLD) and other metabolic syndromes, such as obesity, abnormal blood glucose, and dyslipidemia. The relationship of NAFLD and colorectal adenoma, which is the precursor of colorectal cancer, is worthy of discussion. The aim of this study was to investigate the association between colorectal adenoma and NAFLD, colorectal adenoma and metabolic syndrome in a Chinese Han population. Methods: This retrospective study analyzed the relationship between NAFLD and colorectal adenoma in 1089 patients in Qingdao municipal hospital. Subjects were divided into a colorectal adenoma group (n = 267) and a control group (n = 822). NAFLD and the controlled attenuation parameter (CAP) value were determined by abdominal ultrasound and FibroScan. Results: Patients with NAFLD in the colorectal adenoma group and the control group represented 142 cases (53.2%) and 360 cases (43.8%), respectively. The mean CAP value in the colorectal adenoma group was significantly higher than that in the control group. The values of body mass index, triglyceride, high-density lipoprotein cholesterol, aspartate aminotransferase, fasting plasma glucose, and uric acid were also significantly higher in the colorectal adenoma group than in the control group. Multifactor logistic regression analysis showed that the sex, NAFLD, CAP, body mass index, triglyceride, aspartate aminotransferase, and fasting plasma glucose were significant risk factors for colorectal adenoma. Besides, NAFLD and CAP value were significant risk factors for colorectal adenoma in males but not in females. Conclusions: NAFLD and metabolic syndrome were tightly associated with the risk of colorectal adenoma in this Chinese Han population. The effect of NAFLD on colorectal adenoma was prominent in males rather than in females. XIA & HE Publishing Inc. 2019-05-04 2019-06-28 /pmc/articles/PMC6609839/ /pubmed/31293908 http://dx.doi.org/10.14218/JCTH.2019.00010 Text en © 2019 Authors. http://creativecommons.org/licenses/by-nc/4.0/ This article has been published under the terms of Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0), which permits noncommercial unrestricted use, distribution, and reproduction in any medium, provided that the following statement is provided. “This article has been published in Journal of Clinical and Translational Hepatology at DOI: 10.14218/JCTH.2019.00010 and can also be viewed on the Journal’s website at http://www.jcthnet.com”.
spellingShingle Original Article
Li, Yuan
Liu, Shousheng
Gao, Yuqiang
Ma, Huan
Zhan, Shuhui
Yang, Yan
Xin, Yongning
Xuan, Shiying
Association between NAFLD and Risk of Colorectal Adenoma in Chinese Han Population
title Association between NAFLD and Risk of Colorectal Adenoma in Chinese Han Population
title_full Association between NAFLD and Risk of Colorectal Adenoma in Chinese Han Population
title_fullStr Association between NAFLD and Risk of Colorectal Adenoma in Chinese Han Population
title_full_unstemmed Association between NAFLD and Risk of Colorectal Adenoma in Chinese Han Population
title_short Association between NAFLD and Risk of Colorectal Adenoma in Chinese Han Population
title_sort association between nafld and risk of colorectal adenoma in chinese han population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609839/
https://www.ncbi.nlm.nih.gov/pubmed/31293908
http://dx.doi.org/10.14218/JCTH.2019.00010
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