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An Update on the Role of Adipose Tissues in Psoriasis

Psoriasis is a common chronic inflammatory skin disease that is increasingly being recognized as a disease that not only affects the skin but also has multi-systemic implications. The pathophysiological link between psoriasis and obesity is becoming increasingly elucidated by recent studies. The cro...

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Autores principales: Wong, Yisheng, Nakamizo, Satoshi, Tan, Kahbing J., Kabashima, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609873/
https://www.ncbi.nlm.nih.gov/pubmed/31316526
http://dx.doi.org/10.3389/fimmu.2019.01507
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author Wong, Yisheng
Nakamizo, Satoshi
Tan, Kahbing J.
Kabashima, Kenji
author_facet Wong, Yisheng
Nakamizo, Satoshi
Tan, Kahbing J.
Kabashima, Kenji
author_sort Wong, Yisheng
collection PubMed
description Psoriasis is a common chronic inflammatory skin disease that is increasingly being recognized as a disease that not only affects the skin but also has multi-systemic implications. The pathophysiological link between psoriasis and obesity is becoming increasingly elucidated by recent studies. The cross-talk between adipocytes and the immune system via various mediators such as adipokines could explain how obesity contributes to psoriasis. The effects of obesity on adipocytes include upregulation of pro-inflammatory adipokines such as leptin and resistin, downregulation of anti-inflammatory adipokine, and also the stimulation of pro-inflammatory cytokine production by macrophages. This article provides an update on the role of adipose tissues in psoriasis.
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spelling pubmed-66098732019-07-17 An Update on the Role of Adipose Tissues in Psoriasis Wong, Yisheng Nakamizo, Satoshi Tan, Kahbing J. Kabashima, Kenji Front Immunol Immunology Psoriasis is a common chronic inflammatory skin disease that is increasingly being recognized as a disease that not only affects the skin but also has multi-systemic implications. The pathophysiological link between psoriasis and obesity is becoming increasingly elucidated by recent studies. The cross-talk between adipocytes and the immune system via various mediators such as adipokines could explain how obesity contributes to psoriasis. The effects of obesity on adipocytes include upregulation of pro-inflammatory adipokines such as leptin and resistin, downregulation of anti-inflammatory adipokine, and also the stimulation of pro-inflammatory cytokine production by macrophages. This article provides an update on the role of adipose tissues in psoriasis. Frontiers Media S.A. 2019-06-28 /pmc/articles/PMC6609873/ /pubmed/31316526 http://dx.doi.org/10.3389/fimmu.2019.01507 Text en Copyright © 2019 Wong, Nakamizo, Tan and Kabashima. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wong, Yisheng
Nakamizo, Satoshi
Tan, Kahbing J.
Kabashima, Kenji
An Update on the Role of Adipose Tissues in Psoriasis
title An Update on the Role of Adipose Tissues in Psoriasis
title_full An Update on the Role of Adipose Tissues in Psoriasis
title_fullStr An Update on the Role of Adipose Tissues in Psoriasis
title_full_unstemmed An Update on the Role of Adipose Tissues in Psoriasis
title_short An Update on the Role of Adipose Tissues in Psoriasis
title_sort update on the role of adipose tissues in psoriasis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609873/
https://www.ncbi.nlm.nih.gov/pubmed/31316526
http://dx.doi.org/10.3389/fimmu.2019.01507
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