Prostacyclin Analogue–Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats

Intravenously injected ONO-1301–containing nanoparticles (ONO-1301NPs), unlike an ONO-1301 solution, selectively accumulated in the ischemia/reperfusion (I/R)-injured myocardium of rats and contributed to the prolonged retention of ONO-1301 in the targeted myocardial tissue. In the ischemic area, pr...

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Detalles Bibliográficos
Autores principales: Yajima, Shin, Miyagawa, Shigeru, Fukushima, Satsuki, Sakai, Yoshiki, Iseoka, Hiroko, Harada, Akima, Isohashi, Kayako, Horitsugi, Genki, Mori, Yuki, Shiozaki, Motoko, Ohkawara, Hirotatsu, Sakaniwa, Ryoto, Hatazawa, Jun, Yoshioka, Yoshichika, Sawa, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609885/
https://www.ncbi.nlm.nih.gov/pubmed/31312756
http://dx.doi.org/10.1016/j.jacbts.2018.12.006
Descripción
Sumario:Intravenously injected ONO-1301–containing nanoparticles (ONO-1301NPs), unlike an ONO-1301 solution, selectively accumulated in the ischemia/reperfusion (I/R)-injured myocardium of rats and contributed to the prolonged retention of ONO-1301 in the targeted myocardial tissue. In the ischemic area, proangiogenic cytokines were up-regulated and inflammatory cytokines were down-regulated upon ONO-1301NP administration. Consequently, ONO-1301NP–injected rats exhibited a smaller infarct size, better-preserved capillary networks, and a better-preserved myocardial blood flow at 24 h after I/R injury, compared with those in vehicle-injected or ONO-1301 solution–injected rats. ONO-1301NPs attenuate the myocardial I/R injury via proangiogenic and anti-inflammatory effects of the drug.

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