Prostacyclin Analogue–Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats

Intravenously injected ONO-1301–containing nanoparticles (ONO-1301NPs), unlike an ONO-1301 solution, selectively accumulated in the ischemia/reperfusion (I/R)-injured myocardium of rats and contributed to the prolonged retention of ONO-1301 in the targeted myocardial tissue. In the ischemic area, pr...

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Autores principales: Yajima, Shin, Miyagawa, Shigeru, Fukushima, Satsuki, Sakai, Yoshiki, Iseoka, Hiroko, Harada, Akima, Isohashi, Kayako, Horitsugi, Genki, Mori, Yuki, Shiozaki, Motoko, Ohkawara, Hirotatsu, Sakaniwa, Ryoto, Hatazawa, Jun, Yoshioka, Yoshichika, Sawa, Yoshiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609885/
https://www.ncbi.nlm.nih.gov/pubmed/31312756
http://dx.doi.org/10.1016/j.jacbts.2018.12.006
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author Yajima, Shin
Miyagawa, Shigeru
Fukushima, Satsuki
Sakai, Yoshiki
Iseoka, Hiroko
Harada, Akima
Isohashi, Kayako
Horitsugi, Genki
Mori, Yuki
Shiozaki, Motoko
Ohkawara, Hirotatsu
Sakaniwa, Ryoto
Hatazawa, Jun
Yoshioka, Yoshichika
Sawa, Yoshiki
author_facet Yajima, Shin
Miyagawa, Shigeru
Fukushima, Satsuki
Sakai, Yoshiki
Iseoka, Hiroko
Harada, Akima
Isohashi, Kayako
Horitsugi, Genki
Mori, Yuki
Shiozaki, Motoko
Ohkawara, Hirotatsu
Sakaniwa, Ryoto
Hatazawa, Jun
Yoshioka, Yoshichika
Sawa, Yoshiki
author_sort Yajima, Shin
collection PubMed
description Intravenously injected ONO-1301–containing nanoparticles (ONO-1301NPs), unlike an ONO-1301 solution, selectively accumulated in the ischemia/reperfusion (I/R)-injured myocardium of rats and contributed to the prolonged retention of ONO-1301 in the targeted myocardial tissue. In the ischemic area, proangiogenic cytokines were up-regulated and inflammatory cytokines were down-regulated upon ONO-1301NP administration. Consequently, ONO-1301NP–injected rats exhibited a smaller infarct size, better-preserved capillary networks, and a better-preserved myocardial blood flow at 24 h after I/R injury, compared with those in vehicle-injected or ONO-1301 solution–injected rats. ONO-1301NPs attenuate the myocardial I/R injury via proangiogenic and anti-inflammatory effects of the drug.
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spelling pubmed-66098852019-07-16 Prostacyclin Analogue–Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats Yajima, Shin Miyagawa, Shigeru Fukushima, Satsuki Sakai, Yoshiki Iseoka, Hiroko Harada, Akima Isohashi, Kayako Horitsugi, Genki Mori, Yuki Shiozaki, Motoko Ohkawara, Hirotatsu Sakaniwa, Ryoto Hatazawa, Jun Yoshioka, Yoshichika Sawa, Yoshiki JACC Basic Transl Sci PRECLINICAL RESEARCH Intravenously injected ONO-1301–containing nanoparticles (ONO-1301NPs), unlike an ONO-1301 solution, selectively accumulated in the ischemia/reperfusion (I/R)-injured myocardium of rats and contributed to the prolonged retention of ONO-1301 in the targeted myocardial tissue. In the ischemic area, proangiogenic cytokines were up-regulated and inflammatory cytokines were down-regulated upon ONO-1301NP administration. Consequently, ONO-1301NP–injected rats exhibited a smaller infarct size, better-preserved capillary networks, and a better-preserved myocardial blood flow at 24 h after I/R injury, compared with those in vehicle-injected or ONO-1301 solution–injected rats. ONO-1301NPs attenuate the myocardial I/R injury via proangiogenic and anti-inflammatory effects of the drug. Elsevier 2019-05-08 /pmc/articles/PMC6609885/ /pubmed/31312756 http://dx.doi.org/10.1016/j.jacbts.2018.12.006 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle PRECLINICAL RESEARCH
Yajima, Shin
Miyagawa, Shigeru
Fukushima, Satsuki
Sakai, Yoshiki
Iseoka, Hiroko
Harada, Akima
Isohashi, Kayako
Horitsugi, Genki
Mori, Yuki
Shiozaki, Motoko
Ohkawara, Hirotatsu
Sakaniwa, Ryoto
Hatazawa, Jun
Yoshioka, Yoshichika
Sawa, Yoshiki
Prostacyclin Analogue–Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats
title Prostacyclin Analogue–Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats
title_full Prostacyclin Analogue–Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats
title_fullStr Prostacyclin Analogue–Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats
title_full_unstemmed Prostacyclin Analogue–Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats
title_short Prostacyclin Analogue–Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats
title_sort prostacyclin analogue–loaded nanoparticles attenuate myocardial ischemia/reperfusion injury in rats
topic PRECLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609885/
https://www.ncbi.nlm.nih.gov/pubmed/31312756
http://dx.doi.org/10.1016/j.jacbts.2018.12.006
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