Glycemic control and survival of patients with coexisting diabetes mellitus and gastric or esophageal cancer

AIM: To examine effects of diabetes mellitus (DM) on survival in gastric or esophageal (GE) cancer and the cancers’ effects on glycemic control. MATERIALS & METHODS: Patients with GE cancer with and without DM were matched 1 to 1 (2006–2016). Characteristics were compared and survival assessed w...

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Detalles Bibliográficos
Autores principales: Karlin, Nina J, Buras, Matthew R, Kosiorek, Heidi E, Verona, Patricia M, Cook, Curtiss B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609893/
https://www.ncbi.nlm.nih.gov/pubmed/31285842
http://dx.doi.org/10.2144/fsoa-2019-0038
Descripción
Sumario:AIM: To examine effects of diabetes mellitus (DM) on survival in gastric or esophageal (GE) cancer and the cancers’ effects on glycemic control. MATERIALS & METHODS: Patients with GE cancer with and without DM were matched 1 to 1 (2006–2016). Characteristics were compared and survival assessed with Kaplan–Meier method and Cox regression. Mixed models compared hemoglobin A(1c) and glucose over time. RESULTS: Among DM cases, mean hemoglobin A(1c) was 6.8% in the year after cancer diagnosis. Three-year overall survival was 46% with DM versus 52% without DM (hazard ratio [95% CI]: 1.95 [1.14–3.34]; p = 0.02). CONCLUSION: GE cancer and its treatment did not affect glycemic control. Risks of death and progression were greater for patients with DM than patients without DM.

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