Chlorambucil targets BRCA1/2‐deficient tumours and counteracts PARP inhibitor resistance

Due to compromised homologous recombination (HR) repair, BRCA1‐ and BRCA2‐mutated tumours accumulate DNA damage and genomic rearrangements conducive of tumour progression. To identify drugs that target specifically BRCA2‐deficient cells, we screened a chemical library containing compounds in clinica...

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Detalles Bibliográficos
Autores principales: Tacconi, Eliana MC, Badie, Sophie, De Gregoriis, Giuliana, Reisländer, Timo, Lai, Xianning, Porru, Manuela, Folio, Cecilia, Moore, John, Kopp, Arnaud, Baguña Torres, Júlia, Sneddon, Deborah, Green, Marcus, Dedic, Simon, Lee, Jonathan W, Batra, Ankita Sati, Rueda, Oscar M, Bruna, Alejandra, Leonetti, Carlo, Caldas, Carlos, Cornelissen, Bart, Brino, Laurent, Ryan, Anderson, Biroccio, Annamaria, Tarsounas, Madalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609913/
https://www.ncbi.nlm.nih.gov/pubmed/31273933
http://dx.doi.org/10.15252/emmm.201809982

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