Experiencia con colistina nebulizada en pacientes con bronquiectasias no fibrosis quística colonizadas por Pseudomonas aeruginosa

INTRODUCTION: Chronic colonisation/infection by Pseu-domonas aeruginosa of the bronchiectasis is related to a faster deterioration of lung function, an increase in the number of exac-erbations and a higher morbidity and mortality. Nebulised colistin decreases bacteria load. Therefore, a reduction in the number and in the severity of exacerbations and a delay of pulmonary decline is expected. The main objective is to evaluate if the treatment with nebulised colistin, for at least 6 months reduces the number of admissions and visits to the emergency department. MATERIAL AND METHODS: Observational, retrospective and non-interventionist study carried out in an organization-al structure with an integrated management. Patients with non-cystic fibrosis bronchiectasis colonised / infected by P. aeruginosa, older than 18 years, were selected. Patients must have received nebulized colistin during at least 6 months. Clinical, microbiological and therapeutic data from the pa-tients were collected from the SERGAS computerized clinical history (IANUS(®) v.4.20.0503) and the electronic prescrip-tion, which were divided into two time periods: 1) 6 months pre-treatment and during the treatment and 2) 12 months pre-treatment and during the treatment, in those who com-pleted 1 year of treatment. RESULTS: Forty-four patients were included and of these, 29 (65.9%) had a follow-up of 12 months. The use of nebu-lized colistin decreased significantly the number of visits to the emergency (at 6 months), the frequency and duration of hos-pitalizations admissions (at 6 and 12 months), the antibiotic consumption (at 6 and 12 months) and the positive cultures. The treatment was well tolerated in almost all patients. CONCLUSIONS: The treatment with nebulised colistin during 6 and 12 months of non-cystic fibrosis bronchiectasis, colo-nised/infected by P. aeruginosa, seems beneficial for the pa-tient, from the clinical and quality of life point of view, and could reduce the economic cost of the process.