Cargando…

Genetic Regulation of Enoyl-CoA Hydratase Domain-Containing 3 in Adipose Tissue Determines Insulin Sensitivity in African Americans and Europeans

Insulin resistance (IR) is a harbinger of type 2 diabetes (T2D) and partly determined by genetic factors. However, genetically regulated mechanisms of IR remain poorly understood. Using gene expression, genotype, and insulin sensitivity data from the African American Genetics of Metabolism and Expre...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sharma, Neeraj K., Chuang Key, Chia-Chi, Civelek, Mete, Wabitsch, Martin, Comeau, Mary E., Langefeld, Carl D., Parks, John S., Das, Swapan K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2019
Materias:	Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609988/ https://www.ncbi.nlm.nih.gov/pubmed/31010960 http://dx.doi.org/10.2337/db18-1229

Ejemplares similares

Transferability and Fine Mapping of Type 2 Diabetes Loci in African Americans: The Candidate Gene Association Resource Plus Study
por: Ng, Maggie C.Y., et al.
Publicado: (2013)

Hyperglycemia and a Common Variant of GCKR Are Associated With the Levels of Eight Amino Acids in 9,369 Finnish Men
por: Stančáková, Alena, et al.
Publicado: (2012)

DHA Supplementation Attenuates Inflammation-Associated Gene Expression in the Mammary Gland of Lactating Mothers Who Deliver Preterm
por: Adams, Joselyn M, et al.
Publicado: (2022)

The Plasma Proteome Is Associated with Anthropometric Status of Undernourished Nepalese School-Aged Children(1)(2)(3)
por: Lee, Sun Eun, et al.
Publicado: (2017)

Enoyl-CoA hydratase mediates polyhydroxyalkanoate mobilization in Haloferax mediterranei
por: Liu, Guiming, et al.
Publicado: (2016)

Biosynthesis of Vanillin by Rational Design of Enoyl-CoA Hydratase/Lyase
por: Ye, Qi, et al.
Publicado: (2023)

Metabolomic Changes in Serum of Children with Different Clinical Diagnoses of Malnutrition(1)(2)(3)
por: Di Giovanni, Valeria, et al.
Publicado: (2016)

Metabolic Footprinting of Fermented Milk Consumption in Serum of Healthy Men
por: Pimentel, Grégory, et al.
Publicado: (2018)

Identification of Milk and Cheese Intake Biomarkers in Healthy Adults Reveals High Interindividual Variability of Lewis System–Related Oligosaccharides
por: Pimentel, Grégory, et al.
Publicado: (2020)

Treatment with Nitrate, but Not Nitrite, Lowers the Oxygen Cost of Exercise and Decreases Glycolytic Intermediates While Increasing Fatty Acid Metabolites in Exercised Zebrafish
por: Axton, Elizabeth R, et al.
Publicado: (2019)

Personalized Profiling Reveals Donor- and Lactation-Specific Trends in the Human Milk Proteome and Peptidome
por: Zhu, Jing, et al.
Publicado: (2021)

Urine Metabolite Profiles and Nutrient Intake Based on 4-Day Weighed Food Diary in Habitual Vegans, Vegetarians, and Omnivores
por: Lindqvist, Helen M, et al.
Publicado: (2020)

Plasma MicroRNA Signature of Alcohol Consumption: The Rotterdam Study
por: Karabegović, Irma, et al.
Publicado: (2022)

Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors
por: Fall, Tove, et al.
Publicado: (2015)

Transcriptional Dynamics During Human Adipogenesis and Its Link to Adipose Morphology and Distribution
por: Ehrlund, Anna, et al.
Publicado: (2017)

Cell-Type Composition Affects Adipose Gene Expression Associations With Cardiometabolic Traits
por: Brotman, Sarah M., et al.
Publicado: (2023)

Expression of clock gene Dbp in omental and mesenteric adipose tissue in patients with type 2 diabetes
por: Ushijima, Kentaro, et al.
Publicado: (2020)

Nontargeted and Targeted Metabolomic Profiling Reveals Novel Metabolite Biomarkers of Incident Diabetes in African Americans
por: Chen, Zsu-Zsu, et al.
Publicado: (2022)

Exploring triheptanoin as treatment for short chain enoyl CoA hydratase deficiency
por: Engelstad, Kristin, et al.
Publicado: (2021)

Improved Performance of Dynamic Measures of Insulin Response Over Surrogate Indices to Identify Genetic Contributors of Type 2 Diabetes: The GUARDIAN Consortium
por: Palmer, Nicholette D., et al.
Publicado: (2016)

Differential DNA methylation profile in infants born small-for-gestational-age: association with markers of adiposity and insulin resistance from birth to age 24 months
por: Diaz, Marta, et al.
Publicado: (2020)

Enoyl-CoA hydratase/3-hydroxyacyl CoA dehydrogenase is essential for the production of DHA in zebrafish
por: Yang, Gang, et al.
Publicado: (2022)

Monocyte miRNAs Are Associated With Type 2 Diabetes
por: Parker, Daniel C., et al.
Publicado: (2022)

Mitochondrial DNA Coding and Control Region Variants as Genetic Risk Factors for Type 2 Diabetes
por: Liou, Chia-Wei, et al.
Publicado: (2012)

Genetic Variants Associated With Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium
por: Palmer, Nicholette D., et al.
Publicado: (2015)

Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients
por: Zhang, Ya-Kun, et al.
Publicado: (2017)

A putative enoyl-CoA hydratase contributes to biofilm formation and the antibiotic tolerance of Achromobacter xylosoxidans
por: Cameron, Lydia C., et al.
Publicado: (2019)

Epigenome-Wide Association Study of Fasting Measures of Glucose, Insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network Study
por: Hidalgo, Bertha, et al.
Publicado: (2014)

Motifs of Three HLA-DQ Amino Acid Residues (α44, β57, β135) Capture Full Association With the Risk of Type 1 Diabetes in DQ2 and DQ8 Children
por: Zhao, Lue Ping, et al.
Publicado: (2020)

Dissecting Human Gene Functions Regulating Islet Development With Targeted Gene Transduction
por: Pauerstein, Philip T., et al.
Publicado: (2015)

Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4, and 5 Include Potentially Causal Residues Responsible for the Risk of Childhood Type 1 Diabetes
por: Zhao, Lue Ping, et al.
Publicado: (2019)

Metabolomic markers of glucose regulation after a lifestyle intervention in prediabetes
por: Sevilla-Gonzalez, Magdalena del Rocio, et al.
Publicado: (2022)

Genetic Predisposition to High Blood Pressure Associates With Cardiovascular Complications Among Patients With Type 2 Diabetes: Two Independent Studies
por: Qi, Qibin, et al.
Publicado: (2012)

Genetic Determinants of Glycated Hemoglobin in Type 1 Diabetes
por: Syreeni, Anna, et al.
Publicado: (2019)

Genome-Wide Association Study for Type 2 Diabetes in Indians Identifies a New Susceptibility Locus at 2q21
por: Tabassum, Rubina, et al.
Publicado: (2013)

Effects of Non-HLA Gene Polymorphisms on Development of Islet Autoimmunity and Type 1 Diabetes in a Population With High-Risk HLA-DR,DQ Genotypes
por: Steck, Andrea K., et al.
Publicado: (2012)

Predictive Modeling of Type 1 Diabetes Stages Using Disparate Data Sources
por: Frohnert, Brigitte I., et al.
Publicado: (2020)

Epigenetic Regulation of Placenta-Specific 8 Contributes to Altered Function of Endothelial Colony-Forming Cells Exposed to Intrauterine Gestational Diabetes Mellitus
por: Blue, Emily K., et al.
Publicado: (2015)

Genetic Loci and Physiologic Pathways Involved in Gestational Diabetes Mellitus Implicated Through Clustering
por: Powe, Camille E., et al.
Publicado: (2021)

Novel Association Between Immune-Mediated Susceptibility Loci and Persistent Autoantibody Positivity in Type 1 Diabetes
por: Brorsson, Caroline A., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_p8j7dl2iliv3arl046lfdnvfi0