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Breastfeeding, Cellular Immune Activation, and Myocardial Recovery in Peripartum Cardiomyopathy
The etiology of peripartum cardiomyopathy remains unknown. One hypothesis is that an increase in the 16-kDa form of prolactin is pathogenic and suggests that breastfeeding may worsen peripartum cardiomyopathy by increasing prolactin, while bromocriptine, which blocks prolactin release, may be therap...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609998/ https://www.ncbi.nlm.nih.gov/pubmed/31312753 http://dx.doi.org/10.1016/j.jacbts.2019.01.010 |
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author | Koczo, Agnes Marino, Amy Jeyabalan, Arun Elkayam, Uri Cooper, Leslie T. Fett, James Briller, Joan Hsich, Eileen Blauwet, Lori McTiernan, Charles Morel, Penelope A. Hanley-Yanez, Karen McNamara, Dennis M. |
author_facet | Koczo, Agnes Marino, Amy Jeyabalan, Arun Elkayam, Uri Cooper, Leslie T. Fett, James Briller, Joan Hsich, Eileen Blauwet, Lori McTiernan, Charles Morel, Penelope A. Hanley-Yanez, Karen McNamara, Dennis M. |
author_sort | Koczo, Agnes |
collection | PubMed |
description | The etiology of peripartum cardiomyopathy remains unknown. One hypothesis is that an increase in the 16-kDa form of prolactin is pathogenic and suggests that breastfeeding may worsen peripartum cardiomyopathy by increasing prolactin, while bromocriptine, which blocks prolactin release, may be therapeutic. An autoimmune etiology has also been proposed. The authors investigated the impact of breastfeeding on cellular immunity and myocardial recovery for women with peripartum cardiomyopathy in the IPAC (Investigations in Pregnancy Associated Cardiomyopathy) study. Women who breastfed had elevated prolactin, and prolactin levels correlated with elevations in CD8(+) T cells. However, despite elevated prolactin and cytotoxic T cell subsets, myocardial recovery was not impaired in breastfeeding women. |
format | Online Article Text |
id | pubmed-6609998 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-66099982019-07-16 Breastfeeding, Cellular Immune Activation, and Myocardial Recovery in Peripartum Cardiomyopathy Koczo, Agnes Marino, Amy Jeyabalan, Arun Elkayam, Uri Cooper, Leslie T. Fett, James Briller, Joan Hsich, Eileen Blauwet, Lori McTiernan, Charles Morel, Penelope A. Hanley-Yanez, Karen McNamara, Dennis M. JACC Basic Transl Sci CLINICAL RESEARCH The etiology of peripartum cardiomyopathy remains unknown. One hypothesis is that an increase in the 16-kDa form of prolactin is pathogenic and suggests that breastfeeding may worsen peripartum cardiomyopathy by increasing prolactin, while bromocriptine, which blocks prolactin release, may be therapeutic. An autoimmune etiology has also been proposed. The authors investigated the impact of breastfeeding on cellular immunity and myocardial recovery for women with peripartum cardiomyopathy in the IPAC (Investigations in Pregnancy Associated Cardiomyopathy) study. Women who breastfed had elevated prolactin, and prolactin levels correlated with elevations in CD8(+) T cells. However, despite elevated prolactin and cytotoxic T cell subsets, myocardial recovery was not impaired in breastfeeding women. Elsevier 2019-06-24 /pmc/articles/PMC6609998/ /pubmed/31312753 http://dx.doi.org/10.1016/j.jacbts.2019.01.010 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | CLINICAL RESEARCH Koczo, Agnes Marino, Amy Jeyabalan, Arun Elkayam, Uri Cooper, Leslie T. Fett, James Briller, Joan Hsich, Eileen Blauwet, Lori McTiernan, Charles Morel, Penelope A. Hanley-Yanez, Karen McNamara, Dennis M. Breastfeeding, Cellular Immune Activation, and Myocardial Recovery in Peripartum Cardiomyopathy |
title | Breastfeeding, Cellular Immune Activation, and Myocardial Recovery in Peripartum Cardiomyopathy |
title_full | Breastfeeding, Cellular Immune Activation, and Myocardial Recovery in Peripartum Cardiomyopathy |
title_fullStr | Breastfeeding, Cellular Immune Activation, and Myocardial Recovery in Peripartum Cardiomyopathy |
title_full_unstemmed | Breastfeeding, Cellular Immune Activation, and Myocardial Recovery in Peripartum Cardiomyopathy |
title_short | Breastfeeding, Cellular Immune Activation, and Myocardial Recovery in Peripartum Cardiomyopathy |
title_sort | breastfeeding, cellular immune activation, and myocardial recovery in peripartum cardiomyopathy |
topic | CLINICAL RESEARCH |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6609998/ https://www.ncbi.nlm.nih.gov/pubmed/31312753 http://dx.doi.org/10.1016/j.jacbts.2019.01.010 |
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