Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities

Systemic hyperuricemia (HyUA) in obesity/type 2 diabetes facilitated by elevated activity of xanthine oxidoreductase (XOR), which is the sole source of uric acid (UA) in mammals, has been proposed to contribute to the pathogenesis of insulin resistance/dyslipidemia in obesity. Here, the effects of h...

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Detalles Bibliográficos
Autores principales: Harmon, Daniel B., Mandler, W. Kyle, Sipula, Ian J., Dedousis, Nikolaos, Lewis, Sara E., Eckels, Jeremy T., Du, Jianhai, Wang, Yekai, Huckestein, Brydie R., Pagano, Patrick J., Cifuentes-Pagano, Eugenia, Homanics, Gregg E., Van’t Erve, Thomas J., Stefanovic-Racic, Maja, Jurczak, Michael J., O’Doherty, Robert M., Kelley, Eric E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2019
Materias:
Obesity Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610025/
https://www.ncbi.nlm.nih.gov/pubmed/30936145
http://dx.doi.org/10.2337/db18-1198

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