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Identification and characterization of a murine model of BCR-ABL1(+) acute B-lymphoblastic leukemia with central nervous system metastasis
Breakpoint cluster region (BCR)-Abelson murine leukemia (ABL)1(+) acute B-lymphoblastic leukemia (B-ALL) is a disease associated with a dismal prognosis and a high incidence of central nervous system (CNS) metastasis. However, BCR-ABL1(+) B-ALL with CNS infiltration has not been previously character...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610040/ https://www.ncbi.nlm.nih.gov/pubmed/31173268 http://dx.doi.org/10.3892/or.2019.7184 |
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author | Yu, Xiaozhuo Zhang, Hua Yuan, Meng Zhang, Ping Wang, Yang Zheng, Mingzhe Lv, Zhuangwei Odhiambo, Woodvine Otieno Li, Canyu Liu, Chengcheng Ma, Yunfeng Ji, Yanhong |
author_facet | Yu, Xiaozhuo Zhang, Hua Yuan, Meng Zhang, Ping Wang, Yang Zheng, Mingzhe Lv, Zhuangwei Odhiambo, Woodvine Otieno Li, Canyu Liu, Chengcheng Ma, Yunfeng Ji, Yanhong |
author_sort | Yu, Xiaozhuo |
collection | PubMed |
description | Breakpoint cluster region (BCR)-Abelson murine leukemia (ABL)1(+) acute B-lymphoblastic leukemia (B-ALL) is a disease associated with a dismal prognosis and a high incidence of central nervous system (CNS) metastasis. However, BCR-ABL1(+) B-ALL with CNS infiltration has not been previously characterized, at least to the best of our knowledge. In the present study, a murine model of BCR-ABL1(+) B-ALL with CNS metastasis was established using retroviral transduction. The vast majority of BCR-ABL1(+) leukemic cells were found to be immature B cells with a variable proportion of pro-B and pre-B populations. The present results indicated that the BCR-ABL1(+) B-leukemic cells expressed high levels integrin subunit alpha 6 (Itga6) and L-selectin adhesion molecules, and have an intrinsic ability to disseminate and accumulate in CNS tissues, predominantly in meninges. On the whole, these results provide an approach for addressing the mechanisms of BCR-ABL1(+) B-ALL with CNS metastasis and may guide the development of novel therapeutic strategies. |
format | Online Article Text |
id | pubmed-6610040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-66100402019-07-23 Identification and characterization of a murine model of BCR-ABL1(+) acute B-lymphoblastic leukemia with central nervous system metastasis Yu, Xiaozhuo Zhang, Hua Yuan, Meng Zhang, Ping Wang, Yang Zheng, Mingzhe Lv, Zhuangwei Odhiambo, Woodvine Otieno Li, Canyu Liu, Chengcheng Ma, Yunfeng Ji, Yanhong Oncol Rep Articles Breakpoint cluster region (BCR)-Abelson murine leukemia (ABL)1(+) acute B-lymphoblastic leukemia (B-ALL) is a disease associated with a dismal prognosis and a high incidence of central nervous system (CNS) metastasis. However, BCR-ABL1(+) B-ALL with CNS infiltration has not been previously characterized, at least to the best of our knowledge. In the present study, a murine model of BCR-ABL1(+) B-ALL with CNS metastasis was established using retroviral transduction. The vast majority of BCR-ABL1(+) leukemic cells were found to be immature B cells with a variable proportion of pro-B and pre-B populations. The present results indicated that the BCR-ABL1(+) B-leukemic cells expressed high levels integrin subunit alpha 6 (Itga6) and L-selectin adhesion molecules, and have an intrinsic ability to disseminate and accumulate in CNS tissues, predominantly in meninges. On the whole, these results provide an approach for addressing the mechanisms of BCR-ABL1(+) B-ALL with CNS metastasis and may guide the development of novel therapeutic strategies. D.A. Spandidos 2019-08 2019-06-03 /pmc/articles/PMC6610040/ /pubmed/31173268 http://dx.doi.org/10.3892/or.2019.7184 Text en Copyright: © Yu et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Yu, Xiaozhuo Zhang, Hua Yuan, Meng Zhang, Ping Wang, Yang Zheng, Mingzhe Lv, Zhuangwei Odhiambo, Woodvine Otieno Li, Canyu Liu, Chengcheng Ma, Yunfeng Ji, Yanhong Identification and characterization of a murine model of BCR-ABL1(+) acute B-lymphoblastic leukemia with central nervous system metastasis |
title | Identification and characterization of a murine model of BCR-ABL1(+) acute B-lymphoblastic leukemia with central nervous system metastasis |
title_full | Identification and characterization of a murine model of BCR-ABL1(+) acute B-lymphoblastic leukemia with central nervous system metastasis |
title_fullStr | Identification and characterization of a murine model of BCR-ABL1(+) acute B-lymphoblastic leukemia with central nervous system metastasis |
title_full_unstemmed | Identification and characterization of a murine model of BCR-ABL1(+) acute B-lymphoblastic leukemia with central nervous system metastasis |
title_short | Identification and characterization of a murine model of BCR-ABL1(+) acute B-lymphoblastic leukemia with central nervous system metastasis |
title_sort | identification and characterization of a murine model of bcr-abl1(+) acute b-lymphoblastic leukemia with central nervous system metastasis |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610040/ https://www.ncbi.nlm.nih.gov/pubmed/31173268 http://dx.doi.org/10.3892/or.2019.7184 |
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