Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses

Trace elements play important roles in human health, but little is known about their functions in humoral immunity. Here, we show an important role for iron in inducing cyclin E and B cell proliferation. We find that iron-deficient individuals exhibit a significantly reduced antibody response to the...

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Detalles Bibliográficos
Autores principales: Jiang, Yuhang, Li, Cuifeng, Wu, Qian, An, Peng, Huang, Laiquan, Wang, Jia, Chen, Chen, Chen, Xi, Zhang, Fan, Ma, Li, Liu, Sanhong, He, Hanqing, Xie, Shuyun, Sun, Yangbai, Liu, Hanshao, Zhan, Yu, Tao, Yu, Liu, Zhi, Sun, Xiaohua, Hu, Yiming, Wang, Qi, Ye, Deji, Zhang, Jie, Zou, Shanhua, Wang, Ying, Wei, Gang, Liu, Yongzhong, Shi, Yufang, Eugene Chin, Y., Hao, Yongqiang, Wang, Fudi, Zhang, Xiaoren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610088/
https://www.ncbi.nlm.nih.gov/pubmed/31270335
http://dx.doi.org/10.1038/s41467-019-11002-5

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