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Decoupling of timescales reveals sparse convergent CPG network in the adult spinal cord

During the generation of rhythmic movements, most spinal neurons receive an oscillatory synaptic drive. The neuronal architecture underlying this drive is unknown, and the corresponding network size and sparseness have not yet been addressed. If the input originates from a small central pattern gene...

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Autores principales: Radosevic, Marija, Willumsen, Alex, Petersen, Peter C., Lindén, Henrik, Vestergaard, Mikkel, Berg, Rune W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610135/
https://www.ncbi.nlm.nih.gov/pubmed/31270315
http://dx.doi.org/10.1038/s41467-019-10822-9
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author Radosevic, Marija
Willumsen, Alex
Petersen, Peter C.
Lindén, Henrik
Vestergaard, Mikkel
Berg, Rune W.
author_facet Radosevic, Marija
Willumsen, Alex
Petersen, Peter C.
Lindén, Henrik
Vestergaard, Mikkel
Berg, Rune W.
author_sort Radosevic, Marija
collection PubMed
description During the generation of rhythmic movements, most spinal neurons receive an oscillatory synaptic drive. The neuronal architecture underlying this drive is unknown, and the corresponding network size and sparseness have not yet been addressed. If the input originates from a small central pattern generator (CPG) with dense divergent connectivity, it will induce correlated input to all receiving neurons, while sparse convergent wiring will induce a weak correlation, if any. Here, we use pairwise recordings of spinal neurons to measure synaptic correlations and thus infer the wiring architecture qualitatively. A strong correlation on a slow timescale implies functional relatedness and a common source, which will also cause correlation on fast timescale due to shared synaptic connections. However, we consistently find marginal coupling between slow and fast correlations regardless of neuronal identity. This suggests either sparse convergent connectivity or a CPG network with recurrent inhibition that actively decorrelates common input.
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spelling pubmed-66101352019-07-08 Decoupling of timescales reveals sparse convergent CPG network in the adult spinal cord Radosevic, Marija Willumsen, Alex Petersen, Peter C. Lindén, Henrik Vestergaard, Mikkel Berg, Rune W. Nat Commun Article During the generation of rhythmic movements, most spinal neurons receive an oscillatory synaptic drive. The neuronal architecture underlying this drive is unknown, and the corresponding network size and sparseness have not yet been addressed. If the input originates from a small central pattern generator (CPG) with dense divergent connectivity, it will induce correlated input to all receiving neurons, while sparse convergent wiring will induce a weak correlation, if any. Here, we use pairwise recordings of spinal neurons to measure synaptic correlations and thus infer the wiring architecture qualitatively. A strong correlation on a slow timescale implies functional relatedness and a common source, which will also cause correlation on fast timescale due to shared synaptic connections. However, we consistently find marginal coupling between slow and fast correlations regardless of neuronal identity. This suggests either sparse convergent connectivity or a CPG network with recurrent inhibition that actively decorrelates common input. Nature Publishing Group UK 2019-07-03 /pmc/articles/PMC6610135/ /pubmed/31270315 http://dx.doi.org/10.1038/s41467-019-10822-9 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Radosevic, Marija
Willumsen, Alex
Petersen, Peter C.
Lindén, Henrik
Vestergaard, Mikkel
Berg, Rune W.
Decoupling of timescales reveals sparse convergent CPG network in the adult spinal cord
title Decoupling of timescales reveals sparse convergent CPG network in the adult spinal cord
title_full Decoupling of timescales reveals sparse convergent CPG network in the adult spinal cord
title_fullStr Decoupling of timescales reveals sparse convergent CPG network in the adult spinal cord
title_full_unstemmed Decoupling of timescales reveals sparse convergent CPG network in the adult spinal cord
title_short Decoupling of timescales reveals sparse convergent CPG network in the adult spinal cord
title_sort decoupling of timescales reveals sparse convergent cpg network in the adult spinal cord
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610135/
https://www.ncbi.nlm.nih.gov/pubmed/31270315
http://dx.doi.org/10.1038/s41467-019-10822-9
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