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Multiparametric rapid screening of neuronal process pathology for drug target identification in HSP patient-specific neurons

Axonal degeneration is a key pathology of neurodegenerative diseases, including hereditary spastic paraplegia (HSP), a disorder characterized by spasticity in the lower limbs. Treatments for HSP and other neurodegenerative diseases are mainly symptomatic. While iPSC-derived neurons are valuable for...

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Detalles Bibliográficos
Autores principales:	Rehbach, Kristina, Kesavan, Jaideep, Hauser, Stefan, Ritzenhofen, Swetlana, Jungverdorben, Johannes, Schüle, Rebecca, Schöls, Ludger, Peitz, Michael, Brüstle, Oliver
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610147/ https://www.ncbi.nlm.nih.gov/pubmed/31270336 http://dx.doi.org/10.1038/s41598-019-45246-4

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