Increased levels of the megakaryocyte and platelet expressed cysteine proteases stefin A and cystatin A prevent thrombosis

Increased platelet activity occurs in type 2 diabetes mellitus (T2DM) and such platelet dysregulation likely originates from altered megakaryopoiesis. We initiated identification of dysregulated pathways in megakaryocytes in the setting of T2DM. We evaluated through transcriptomic analysis, differen...

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Detalles Bibliográficos
Autores principales: Mezzapesa, Anna, Bastelica, Delphine, Crescence, Lydie, Poggi, Marjorie, Grino, Michel, Peiretti, Franck, Panicot-Dubois, Laurence, Dupont, Annabelle, Valero, René, Maraninchi, Marie, Bordet, Jean-Claude, Alessi, Marie-Christine, Dubois, Christophe, Canault, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610149/
https://www.ncbi.nlm.nih.gov/pubmed/31270351
http://dx.doi.org/10.1038/s41598-019-45805-9

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