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Serum levels of carbohydrate antigen 125 in combination with N-terminal pro-brain natriuretic peptide in patients with acute decompensated heart failure
BACKGROUND/AIMS: Carbohydrate antigen 125 (CA-125) is an emerging prognostic biomarker for heart failure. We aimed to test the long-term prognostic value of CA-125 in combination with N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with acute decompensated heart failure (ADHF). METH...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association of Internal Medicine
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610187/ https://www.ncbi.nlm.nih.gov/pubmed/30616330 http://dx.doi.org/10.3904/kjim.2017.313 |
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author | Yoon, Jae Yong Yang, Dong Heon Cho, Hyun Jun Kim, Nam Kyun Kim, Chang-Yeon Son, Jihyun Roh, Jae-Hyung Jang, Se Yong Bae, Myung Hwan Lee, Jang Hoon Park, Hun Sik Cho, Yongkeun Chae, Shung Chull |
author_facet | Yoon, Jae Yong Yang, Dong Heon Cho, Hyun Jun Kim, Nam Kyun Kim, Chang-Yeon Son, Jihyun Roh, Jae-Hyung Jang, Se Yong Bae, Myung Hwan Lee, Jang Hoon Park, Hun Sik Cho, Yongkeun Chae, Shung Chull |
author_sort | Yoon, Jae Yong |
collection | PubMed |
description | BACKGROUND/AIMS: Carbohydrate antigen 125 (CA-125) is an emerging prognostic biomarker for heart failure. We aimed to test the long-term prognostic value of CA-125 in combination with N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with acute decompensated heart failure (ADHF). METHODS: This observational study included a total of 413 patients (64.1 ± 15.6 yearold, 214 men) with ADHF. All-cause mortality during the 2-year follow-up was investigated for the prognosis. RESULTS: During the follow-up (mean follow-up, 591 ± 233 days), 109 deaths (26.0%) were recorded. In the multivariable analysis model, CA-125 was an independent factor associated with all-cause mortality (log CA-125: hazard ratio, 1.23; 95% confidence interval, 1.02 to 1.48; p = 0.030) together with age, sex, New York Heart Association class, β-blocker, and NT-proBNP. The Kaplan-Meier survival analysis demonstrated that the group with both low marker levels showed the best 2-year survival (87.9%) followed by the group with low NT-proBNP and high CA-125 (76.1%), high NT-proBNP and low CA-125 (64.7%) and high NT-proBNP and high CA-125 levels (54.3%) (p < 0.001). Addition of CA-125 in combination with NT-proBNP and established risk factors further increased the predictive power for mortality in patients with ADHF. CONCLUSIONS: CA-125 was an independent factor associated with all-cause mortality in patients with ADHF. Combination of CA-125 with NT-proBNP significantly improved the prediction of mortality in patients with ADHF. |
format | Online Article Text |
id | pubmed-6610187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-66101872019-07-11 Serum levels of carbohydrate antigen 125 in combination with N-terminal pro-brain natriuretic peptide in patients with acute decompensated heart failure Yoon, Jae Yong Yang, Dong Heon Cho, Hyun Jun Kim, Nam Kyun Kim, Chang-Yeon Son, Jihyun Roh, Jae-Hyung Jang, Se Yong Bae, Myung Hwan Lee, Jang Hoon Park, Hun Sik Cho, Yongkeun Chae, Shung Chull Korean J Intern Med Original Article BACKGROUND/AIMS: Carbohydrate antigen 125 (CA-125) is an emerging prognostic biomarker for heart failure. We aimed to test the long-term prognostic value of CA-125 in combination with N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with acute decompensated heart failure (ADHF). METHODS: This observational study included a total of 413 patients (64.1 ± 15.6 yearold, 214 men) with ADHF. All-cause mortality during the 2-year follow-up was investigated for the prognosis. RESULTS: During the follow-up (mean follow-up, 591 ± 233 days), 109 deaths (26.0%) were recorded. In the multivariable analysis model, CA-125 was an independent factor associated with all-cause mortality (log CA-125: hazard ratio, 1.23; 95% confidence interval, 1.02 to 1.48; p = 0.030) together with age, sex, New York Heart Association class, β-blocker, and NT-proBNP. The Kaplan-Meier survival analysis demonstrated that the group with both low marker levels showed the best 2-year survival (87.9%) followed by the group with low NT-proBNP and high CA-125 (76.1%), high NT-proBNP and low CA-125 (64.7%) and high NT-proBNP and high CA-125 levels (54.3%) (p < 0.001). Addition of CA-125 in combination with NT-proBNP and established risk factors further increased the predictive power for mortality in patients with ADHF. CONCLUSIONS: CA-125 was an independent factor associated with all-cause mortality in patients with ADHF. Combination of CA-125 with NT-proBNP significantly improved the prediction of mortality in patients with ADHF. The Korean Association of Internal Medicine 2019-07 2018-12-31 /pmc/articles/PMC6610187/ /pubmed/30616330 http://dx.doi.org/10.3904/kjim.2017.313 Text en Copyright © 2019 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Yoon, Jae Yong Yang, Dong Heon Cho, Hyun Jun Kim, Nam Kyun Kim, Chang-Yeon Son, Jihyun Roh, Jae-Hyung Jang, Se Yong Bae, Myung Hwan Lee, Jang Hoon Park, Hun Sik Cho, Yongkeun Chae, Shung Chull Serum levels of carbohydrate antigen 125 in combination with N-terminal pro-brain natriuretic peptide in patients with acute decompensated heart failure |
title | Serum levels of carbohydrate antigen 125 in combination with N-terminal pro-brain natriuretic peptide in patients with acute decompensated heart failure |
title_full | Serum levels of carbohydrate antigen 125 in combination with N-terminal pro-brain natriuretic peptide in patients with acute decompensated heart failure |
title_fullStr | Serum levels of carbohydrate antigen 125 in combination with N-terminal pro-brain natriuretic peptide in patients with acute decompensated heart failure |
title_full_unstemmed | Serum levels of carbohydrate antigen 125 in combination with N-terminal pro-brain natriuretic peptide in patients with acute decompensated heart failure |
title_short | Serum levels of carbohydrate antigen 125 in combination with N-terminal pro-brain natriuretic peptide in patients with acute decompensated heart failure |
title_sort | serum levels of carbohydrate antigen 125 in combination with n-terminal pro-brain natriuretic peptide in patients with acute decompensated heart failure |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610187/ https://www.ncbi.nlm.nih.gov/pubmed/30616330 http://dx.doi.org/10.3904/kjim.2017.313 |
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