Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use

Paracetamol poisoning was first reported in 1966. The development of antidotes followed within 10 years, and by 1980 acetylcysteine (NAC) was acknowledged as the optimal therapy available. This article examines the history of the development of NAC and recent developments in its use. We offer sugges...

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Detalles Bibliográficos
Autores principales: Bateman, D. Nicholas, Dear, James W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610312/
https://www.ncbi.nlm.nih.gov/pubmed/31341611
http://dx.doi.org/10.1039/c9tx00002j
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author Bateman, D. Nicholas
Dear, James W.
author_facet Bateman, D. Nicholas
Dear, James W.
author_sort Bateman, D. Nicholas
collection PubMed
description Paracetamol poisoning was first reported in 1966. The development of antidotes followed within 10 years, and by 1980 acetylcysteine (NAC) was acknowledged as the optimal therapy available. This article examines the history of the development of NAC and recent developments in its use. We offer suggestions for improvements in the way NAC may be administered and outline new developments that should have major impacts on the way we manage paracetamol poisoning in the near future.
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spelling pubmed-66103122020-04-29 Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use Bateman, D. Nicholas Dear, James W. Toxicol Res (Camb) Chemistry Paracetamol poisoning was first reported in 1966. The development of antidotes followed within 10 years, and by 1980 acetylcysteine (NAC) was acknowledged as the optimal therapy available. This article examines the history of the development of NAC and recent developments in its use. We offer suggestions for improvements in the way NAC may be administered and outline new developments that should have major impacts on the way we manage paracetamol poisoning in the near future. Royal Society of Chemistry 2019-04-29 /pmc/articles/PMC6610312/ /pubmed/31341611 http://dx.doi.org/10.1039/c9tx00002j Text en This journal is © The Royal Society of Chemistry 2019 http://creativecommons.org/licenses/by-nc/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0)
spellingShingle Chemistry
Bateman, D. Nicholas
Dear, James W.
Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use
title Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use
title_full Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use
title_fullStr Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use
title_full_unstemmed Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use
title_short Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use
title_sort acetylcysteine in paracetamol poisoning: a perspective of 45 years of use
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610312/
https://www.ncbi.nlm.nih.gov/pubmed/31341611
http://dx.doi.org/10.1039/c9tx00002j
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AT dearjamesw acetylcysteineinparacetamolpoisoningaperspectiveof45yearsofuse

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