A Matter of Genes: The Hurdles of Gene Therapy for Epilepsy

Gene therapy has recently advanced to the level of standard of care for several diseases. However, its application to neurological disorders is still in the experimental phase. In this review, we discuss recent advancements in the field that provide optimism on the possibility to have first-in-human...

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Autores principales: Ingusci, Selene, Cattaneo, Stefano, Verlengia, Gianluca, Zucchini, Silvia, Simonato, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Current Review in Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610370/
https://www.ncbi.nlm.nih.gov/pubmed/30838918
http://dx.doi.org/10.1177/1535759718822846
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author Ingusci, Selene
Cattaneo, Stefano
Verlengia, Gianluca
Zucchini, Silvia
Simonato, Michele
author_facet Ingusci, Selene
Cattaneo, Stefano
Verlengia, Gianluca
Zucchini, Silvia
Simonato, Michele
author_sort Ingusci, Selene
collection PubMed
description Gene therapy has recently advanced to the level of standard of care for several diseases. However, its application to neurological disorders is still in the experimental phase. In this review, we discuss recent advancements in the field that provide optimism on the possibility to have first-in-human studies for gene therapy of some forms of epilepsy in the not so distant future.
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spelling pubmed-66103702019-07-24 A Matter of Genes: The Hurdles of Gene Therapy for Epilepsy Ingusci, Selene Cattaneo, Stefano Verlengia, Gianluca Zucchini, Silvia Simonato, Michele Epilepsy Curr Current Review in Basic Science Gene therapy has recently advanced to the level of standard of care for several diseases. However, its application to neurological disorders is still in the experimental phase. In this review, we discuss recent advancements in the field that provide optimism on the possibility to have first-in-human studies for gene therapy of some forms of epilepsy in the not so distant future. SAGE Publications 2019-02-12 /pmc/articles/PMC6610370/ /pubmed/30838918 http://dx.doi.org/10.1177/1535759718822846 Text en © The Author(s) 2019 https://creativecommons.org/licenses/by-nc-nd/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License (https://creativecommons.org/licenses/by-nc-nd/4.0/) which permits non-commercial use, reproduction and distribution of the work as published without adaptation or alteration, without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Current Review in Basic Science
Ingusci, Selene
Cattaneo, Stefano
Verlengia, Gianluca
Zucchini, Silvia
Simonato, Michele
A Matter of Genes: The Hurdles of Gene Therapy for Epilepsy
title A Matter of Genes: The Hurdles of Gene Therapy for Epilepsy
title_full A Matter of Genes: The Hurdles of Gene Therapy for Epilepsy
title_fullStr A Matter of Genes: The Hurdles of Gene Therapy for Epilepsy
title_full_unstemmed A Matter of Genes: The Hurdles of Gene Therapy for Epilepsy
title_short A Matter of Genes: The Hurdles of Gene Therapy for Epilepsy
title_sort matter of genes: the hurdles of gene therapy for epilepsy
topic Current Review in Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610370/
https://www.ncbi.nlm.nih.gov/pubmed/30838918
http://dx.doi.org/10.1177/1535759718822846
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