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Whole Genome Sequencing: Bridging One-Health Surveillance of Foodborne Diseases

Infections caused by pathogens commonly acquired from consumption of food are not always transmitted by that route. They may also be transmitted through contact to animals, other humans or the environment. Additionally, many outbreaks are associated with food contaminated from these non-food sources...

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Autores principales: Gerner-Smidt, Peter, Besser, John, Concepción-Acevedo, Jeniffer, Folster, Jason P., Huffman, Jasmine, Joseph, Lavin A., Kucerova, Zuzana, Nichols, Megin C., Schwensohn, Colin A., Tolar, Beth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610495/
https://www.ncbi.nlm.nih.gov/pubmed/31316960
http://dx.doi.org/10.3389/fpubh.2019.00172
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author Gerner-Smidt, Peter
Besser, John
Concepción-Acevedo, Jeniffer
Folster, Jason P.
Huffman, Jasmine
Joseph, Lavin A.
Kucerova, Zuzana
Nichols, Megin C.
Schwensohn, Colin A.
Tolar, Beth
author_facet Gerner-Smidt, Peter
Besser, John
Concepción-Acevedo, Jeniffer
Folster, Jason P.
Huffman, Jasmine
Joseph, Lavin A.
Kucerova, Zuzana
Nichols, Megin C.
Schwensohn, Colin A.
Tolar, Beth
author_sort Gerner-Smidt, Peter
collection PubMed
description Infections caused by pathogens commonly acquired from consumption of food are not always transmitted by that route. They may also be transmitted through contact to animals, other humans or the environment. Additionally, many outbreaks are associated with food contaminated from these non-food sources. For this reason, such presumed foodborne outbreaks are best investigated through a One Health approach working across human, animal and environmental sectors and disciplines. Outbreak strains or clones that have propagated and continue to evolve in non-human sources and environments often show more sequence variation than observed in typical monoclonal point-source outbreaks. This represents a challenge when using whole genome sequencing (WGS), the new gold standard for molecular surveillance of foodborne pathogens, for outbreak detection and investigation. In this review, using recent examples from outbreaks investigated in the United States (US) some aspects of One Health approaches that have been used successfully to solve such outbreaks are presented. These include using different combinations of flexible WGS based case definition, efficient epidemiological follow-up, traceback, surveillance, and testing of potential food and environmental sources and animal hosts.
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spelling pubmed-66104952019-07-17 Whole Genome Sequencing: Bridging One-Health Surveillance of Foodborne Diseases Gerner-Smidt, Peter Besser, John Concepción-Acevedo, Jeniffer Folster, Jason P. Huffman, Jasmine Joseph, Lavin A. Kucerova, Zuzana Nichols, Megin C. Schwensohn, Colin A. Tolar, Beth Front Public Health Public Health Infections caused by pathogens commonly acquired from consumption of food are not always transmitted by that route. They may also be transmitted through contact to animals, other humans or the environment. Additionally, many outbreaks are associated with food contaminated from these non-food sources. For this reason, such presumed foodborne outbreaks are best investigated through a One Health approach working across human, animal and environmental sectors and disciplines. Outbreak strains or clones that have propagated and continue to evolve in non-human sources and environments often show more sequence variation than observed in typical monoclonal point-source outbreaks. This represents a challenge when using whole genome sequencing (WGS), the new gold standard for molecular surveillance of foodborne pathogens, for outbreak detection and investigation. In this review, using recent examples from outbreaks investigated in the United States (US) some aspects of One Health approaches that have been used successfully to solve such outbreaks are presented. These include using different combinations of flexible WGS based case definition, efficient epidemiological follow-up, traceback, surveillance, and testing of potential food and environmental sources and animal hosts. Frontiers Media S.A. 2019-06-27 /pmc/articles/PMC6610495/ /pubmed/31316960 http://dx.doi.org/10.3389/fpubh.2019.00172 Text en Copyright © 2019 Gerner-Smidt, Besser, Concepción-Acevedo, Folster, Huffman, Joseph, Kucerova, Nichols, Schwensohn and Tolar. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Gerner-Smidt, Peter
Besser, John
Concepción-Acevedo, Jeniffer
Folster, Jason P.
Huffman, Jasmine
Joseph, Lavin A.
Kucerova, Zuzana
Nichols, Megin C.
Schwensohn, Colin A.
Tolar, Beth
Whole Genome Sequencing: Bridging One-Health Surveillance of Foodborne Diseases
title Whole Genome Sequencing: Bridging One-Health Surveillance of Foodborne Diseases
title_full Whole Genome Sequencing: Bridging One-Health Surveillance of Foodborne Diseases
title_fullStr Whole Genome Sequencing: Bridging One-Health Surveillance of Foodborne Diseases
title_full_unstemmed Whole Genome Sequencing: Bridging One-Health Surveillance of Foodborne Diseases
title_short Whole Genome Sequencing: Bridging One-Health Surveillance of Foodborne Diseases
title_sort whole genome sequencing: bridging one-health surveillance of foodborne diseases
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610495/
https://www.ncbi.nlm.nih.gov/pubmed/31316960
http://dx.doi.org/10.3389/fpubh.2019.00172
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