Cargando…

Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau

Liquid–liquid phase separation (LLPS) of proteins enables the formation of non-membrane-bound organelles in cells and is associated with cancer and neurodegeneration. Little is known however about the structure and dynamics of proteins in LLPS conditions, because of the polymorphic nature of liquid-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ambadipudi, Susmitha, Reddy, Jithender G., Biernat, Jacek, Mandelkow, Eckhard, Zweckstetter, Markus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610569/ https://www.ncbi.nlm.nih.gov/pubmed/31341602 http://dx.doi.org/10.1039/c9sc00531e

Ejemplares similares

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau
por: Ambadipudi, Susmitha, et al.
Publicado: (2017)

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution
por: Mukrasch, Marco D, et al.
Publicado: (2009)

Disease‐Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates
por: Savastano, Adriana, et al.
Publicado: (2020)

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau
por: Cabrales Fontela, Yunior, et al.
Publicado: (2017)

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments
por: Kaniyappan, Senthilvelrajan, et al.
Publicado: (2020)

Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils
por: Savastano, Adriana, et al.
Publicado: (2020)

Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity
por: Kumar, Satish, et al.
Publicado: (2014)

Oligomer Formation of Tau Protein Hyperphosphorylated in Cells
por: Tepper, Katharina, et al.
Publicado: (2014)

Initiation and modulation of Tau protein phase separation by the drug suramin
por: Prince, Prabhu Rajaiah, et al.
Publicado: (2023)

A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications
por: Drepper, Friedel, et al.
Publicado: (2021)

Liquid–liquid phase separation of tau: From molecular biophysics to physiology and disease
por: Rai, Sandeep K., et al.
Publicado: (2021)

Interplay between tau and α‐synuclein liquid–liquid phase separation
por: Siegert, Anna, et al.
Publicado: (2021)

Potent Tau Aggregation Inhibitor D‐Peptides Selected against Tau‐Repeat 2 Using Mirror Image Phage Display
por: Malhis, Marwa, et al.
Publicado: (2021)

Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein
por: Majewski, Jaroslaw, et al.
Publicado: (2020)

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex
por: Oroz, Javier, et al.
Publicado: (2018)

Tau and Membranes: Interactions That Promote Folding and Condensation
por: Sallaberry, Chad A., et al.
Publicado: (2021)

Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment
por: Pir, Ghulam Jeelani, et al.
Publicado: (2018)

Tau protein liquid–liquid phase separation can initiate tau aggregation
por: Wegmann, Susanne, et al.
Publicado: (2018)

Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution
por: Ukmar-Godec, T., et al.
Publicado: (2020)

A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro
por: Aillaud, Isabelle, et al.
Publicado: (2022)

In silico design of graphene plasmonic hot-spots
por: Bonatti, Luca, et al.
Publicado: (2022)

Unbiased proteomic profiling reveals the IP3R modulator AHCYL1/IRBIT as a novel interactor of microtubule-associated protein tau
por: Wischhof, Lena, et al.
Publicado: (2022)

Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates
por: Hochmair, Janine, et al.
Publicado: (2022)

Identification of hot spot residues at protein-protein interface
por: Li, Lei, et al.
Publicado: (2006)

Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer’s disease mouse model
por: Green, Claudia, et al.
Publicado: (2019)

Inhibition of Tau aggregation with BSc3094 reduces Tau and decreases cognitive deficits in rTg4510 mice
por: Anglada‐Huguet, Marta, et al.
Publicado: (2021)

Lysine/RNA-interactions drive and regulate biomolecular condensation
por: Ukmar-Godec, Tina, et al.
Publicado: (2019)

Anti-aggregant tau mutant promotes neurogenesis
por: Joseph, Maria, et al.
Publicado: (2017)

Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein
por: Timm, Thomas, et al.
Publicado: (2008)

Identification of hot-spot residues in protein-protein interactions by computational docking
por: Grosdidier, Solène, et al.
Publicado: (2008)

Prediction of binding hot spot residues by using structural and evolutionary parameters
por: Higa, Roberto Hiroshi, et al.
Publicado: (2009)

Predicting and Experimentally Validating Hot-Spot Residues at Protein–Protein Interfaces
por: Ibarra, Amaurys A., et al.
Publicado: (2019)

The release and trans-synaptic transmission of Tau via exosomes
por: Wang, Yipeng, et al.
Publicado: (2017)

Protein binding hot spots and the residue-residue pairing preference: a water exclusion perspective
por: Liu, Qian, et al.
Publicado: (2010)

Domains of Neuronal Microtubule-associated Proteins and Flexural Rigidity of Microtubules
por: Felgner, Harald, et al.
Publicado: (1997)

Extracellular Monomeric Tau Protein Is Sufficient to Initiate the Spread of Tau Protein Pathology
por: Michel, Claire H., et al.
Publicado: (2014)

Identification of a hot-spot to enhance Candida rugosa lipase thermostability by rational design methods
por: Li, Guanlin, et al.
Publicado: (2018)

Computational analysis of hot spots and binding mechanism in the PD-1/PD-L1 interaction
por: Huang, Dading, et al.
Publicado: (2019)

Magnetic tuning of SERS hot spots in polymer-coated magnetic–plasmonic iron–silver nanoparticles
por: Scaramuzza, Stefano, et al.
Publicado: (2019)

Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia
por: Zempel, Hans, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_cm9qst84t8nntj9gm0mr92a4ao