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Engineering switchable and programmable universal CARs for CAR T therapy
A traditional chimeric antigen receptor (CAR) has a fixed design, and one type of CAR T cells can only target one antigen epitope. This rigid design limits clinical application and leads to exceptionally high manufacturing cost. New CARs are being engineered with a modular approach so that the antig...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610960/ https://www.ncbi.nlm.nih.gov/pubmed/31272471 http://dx.doi.org/10.1186/s13045-019-0763-0 |