CDK5-mediated phosphorylation and stabilization of TPX2 promotes hepatocellular tumorigenesis

BACKGROUND: CDK5, an atypical member of the CDK family, play a significant role in the tumorigenesis of multiple organ, but CDK5 and its substrates in genesis and development of HCC is still unclear. METHODS: Expression of CDK5 in HCC tumor and paired adjacent noncancerous tissues from 90 patients w...

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Detalles Bibliográficos
Autores principales: Wang, Fuqiang, Zhao, Wenxing, Gao, Yuehong, Zhou, Jiechao, Li, Huifang, Zhang, Guanyun, Guo, Dong, Xie, Chengrong, Li, Jie, Yin, Zhenyu, Zhang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610961/
https://www.ncbi.nlm.nih.gov/pubmed/31272499
http://dx.doi.org/10.1186/s13046-019-1297-6

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