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Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study
BACKGROUND: An important parameter for survival in patients with esophageal carcinoma is lymph node status. The distribution of lymph node metastases depends on tumor characteristics such as tumor location, histology, invasion depth, and on neoadjuvant treatment. The exact distribution is unknown. N...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610993/ https://www.ncbi.nlm.nih.gov/pubmed/31272485 http://dx.doi.org/10.1186/s12885-019-5761-7 |
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author | Hagens, Eliza R. C. van Berge Henegouwen, Mark I. van Sandick, Johanna W. Cuesta, Miguel A. van der Peet, Donald L. Heisterkamp, Joos Nieuwenhuijzen, Grard A. P. Rosman, Camiel Scheepers, Joris J. G. Sosef, Meindert N. van Hillegersberg, Richard Lagarde, Sjoerd M. Nilsson, Magnus Räsänen, Jari Nafteux, Philippe Pattyn, Piet Hölscher, Arnulf H. Schröder, Wolfgang Schneider, Paul M. Mariette, Christophe Castoro, Carlo Bonavina, Luigi Rosati, Riccardo de Manzoni, Giovanni Mattioli, Sandro Garcia, Josep Roig Pera, Manuel Griffin, Michael Wilkerson, Paul Chaudry, M. Asif Sgromo, Bruno Tucker, Olga Cheong, Edward Moorthy, Krishna Walsh, Thomas N. Reynolds, John Tachimori, Yuji Inoue, Haruhiro Matsubara, Hisahiro Kosugi, Shin-ichi Chen, Haiquan Law, Simon Y. K. Pramesh, C. S. Puntambekar, Shailesh P. Murthy, Sudish Linden, Philip Hofstetter, Wayne L. Kuppusamy, Madhan K. Shen, K. Robert Darling, Gail E. Sabino, Flávio D. Grimminger, Peter P. Meijer, Sybren L. Bergman, Jacques J. G. H. M. Hulshof, Maarten C. C. M. van Laarhoven, Hanneke W. M. Mearadji, Banafsche Bennink, Roel J. Annema, Jouke T. Dijkgraaf, Marcel G. W. Gisbertz, Suzanne S. |
author_facet | Hagens, Eliza R. C. van Berge Henegouwen, Mark I. van Sandick, Johanna W. Cuesta, Miguel A. van der Peet, Donald L. Heisterkamp, Joos Nieuwenhuijzen, Grard A. P. Rosman, Camiel Scheepers, Joris J. G. Sosef, Meindert N. van Hillegersberg, Richard Lagarde, Sjoerd M. Nilsson, Magnus Räsänen, Jari Nafteux, Philippe Pattyn, Piet Hölscher, Arnulf H. Schröder, Wolfgang Schneider, Paul M. Mariette, Christophe Castoro, Carlo Bonavina, Luigi Rosati, Riccardo de Manzoni, Giovanni Mattioli, Sandro Garcia, Josep Roig Pera, Manuel Griffin, Michael Wilkerson, Paul Chaudry, M. Asif Sgromo, Bruno Tucker, Olga Cheong, Edward Moorthy, Krishna Walsh, Thomas N. Reynolds, John Tachimori, Yuji Inoue, Haruhiro Matsubara, Hisahiro Kosugi, Shin-ichi Chen, Haiquan Law, Simon Y. K. Pramesh, C. S. Puntambekar, Shailesh P. Murthy, Sudish Linden, Philip Hofstetter, Wayne L. Kuppusamy, Madhan K. Shen, K. Robert Darling, Gail E. Sabino, Flávio D. Grimminger, Peter P. Meijer, Sybren L. Bergman, Jacques J. G. H. M. Hulshof, Maarten C. C. M. van Laarhoven, Hanneke W. M. Mearadji, Banafsche Bennink, Roel J. Annema, Jouke T. Dijkgraaf, Marcel G. W. Gisbertz, Suzanne S. |
author_sort | Hagens, Eliza R. C. |
collection | PubMed |
description | BACKGROUND: An important parameter for survival in patients with esophageal carcinoma is lymph node status. The distribution of lymph node metastases depends on tumor characteristics such as tumor location, histology, invasion depth, and on neoadjuvant treatment. The exact distribution is unknown. Neoadjuvant treatment and surgical strategy depends on the distribution pattern of nodal metastases but consensus on the extent of lymphadenectomy has not been reached. The aim of this study is to determine the distribution of lymph node metastases in patients with resectable esophageal or gastro-esophageal junction carcinoma in whom a transthoracic esophagectomy with a 2- or 3-field lymphadenectomy is performed. This can be the foundation for a uniform worldwide staging system and establishment of the optimal surgical strategy for esophageal cancer patients. METHODS: The TIGER study is an international observational cohort study with 50 participating centers. Patients with a resectable esophageal or gastro-esophageal junction carcinoma in whom a transthoracic esophagectomy with a 2- or 3-field lymphadenectomy is performed in participating centers will be included. All lymph node stations will be excised and separately individually analyzed by pathological examination. The aim is to include 5000 patients. The primary endpoint is the distribution of lymph node metastases in esophageal and esophago-gastric junction carcinoma specimens following transthoracic esophagectomy with at least 2-field lymphadenectomy in relation to tumor histology, tumor location, invasion depth, number of lymph nodes and lymph node metastases, pre-operative diagnostics, neo-adjuvant therapy and (disease free) survival. DISCUSSION: The TIGER study will provide a roadmap of the location of lymph node metastases in relation to tumor histology, tumor location, invasion depth, number of lymph nodes and lymph node metastases, pre-operative diagnostics, neo-adjuvant therapy and survival. Patient-tailored treatment can be developed based on these results, such as the optimal radiation field and extent of lymphadenectomy based on the primary tumor characteristics. TRIAL REGISTRATION: NCT03222895, date of registration: July 19th, 2017. |
format | Online Article Text |
id | pubmed-6610993 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-66109932019-07-16 Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study Hagens, Eliza R. C. van Berge Henegouwen, Mark I. van Sandick, Johanna W. Cuesta, Miguel A. van der Peet, Donald L. Heisterkamp, Joos Nieuwenhuijzen, Grard A. P. Rosman, Camiel Scheepers, Joris J. G. Sosef, Meindert N. van Hillegersberg, Richard Lagarde, Sjoerd M. Nilsson, Magnus Räsänen, Jari Nafteux, Philippe Pattyn, Piet Hölscher, Arnulf H. Schröder, Wolfgang Schneider, Paul M. Mariette, Christophe Castoro, Carlo Bonavina, Luigi Rosati, Riccardo de Manzoni, Giovanni Mattioli, Sandro Garcia, Josep Roig Pera, Manuel Griffin, Michael Wilkerson, Paul Chaudry, M. Asif Sgromo, Bruno Tucker, Olga Cheong, Edward Moorthy, Krishna Walsh, Thomas N. Reynolds, John Tachimori, Yuji Inoue, Haruhiro Matsubara, Hisahiro Kosugi, Shin-ichi Chen, Haiquan Law, Simon Y. K. Pramesh, C. S. Puntambekar, Shailesh P. Murthy, Sudish Linden, Philip Hofstetter, Wayne L. Kuppusamy, Madhan K. Shen, K. Robert Darling, Gail E. Sabino, Flávio D. Grimminger, Peter P. Meijer, Sybren L. Bergman, Jacques J. G. H. M. Hulshof, Maarten C. C. M. van Laarhoven, Hanneke W. M. Mearadji, Banafsche Bennink, Roel J. Annema, Jouke T. Dijkgraaf, Marcel G. W. Gisbertz, Suzanne S. BMC Cancer Study Protocol BACKGROUND: An important parameter for survival in patients with esophageal carcinoma is lymph node status. The distribution of lymph node metastases depends on tumor characteristics such as tumor location, histology, invasion depth, and on neoadjuvant treatment. The exact distribution is unknown. Neoadjuvant treatment and surgical strategy depends on the distribution pattern of nodal metastases but consensus on the extent of lymphadenectomy has not been reached. The aim of this study is to determine the distribution of lymph node metastases in patients with resectable esophageal or gastro-esophageal junction carcinoma in whom a transthoracic esophagectomy with a 2- or 3-field lymphadenectomy is performed. This can be the foundation for a uniform worldwide staging system and establishment of the optimal surgical strategy for esophageal cancer patients. METHODS: The TIGER study is an international observational cohort study with 50 participating centers. Patients with a resectable esophageal or gastro-esophageal junction carcinoma in whom a transthoracic esophagectomy with a 2- or 3-field lymphadenectomy is performed in participating centers will be included. All lymph node stations will be excised and separately individually analyzed by pathological examination. The aim is to include 5000 patients. The primary endpoint is the distribution of lymph node metastases in esophageal and esophago-gastric junction carcinoma specimens following transthoracic esophagectomy with at least 2-field lymphadenectomy in relation to tumor histology, tumor location, invasion depth, number of lymph nodes and lymph node metastases, pre-operative diagnostics, neo-adjuvant therapy and (disease free) survival. DISCUSSION: The TIGER study will provide a roadmap of the location of lymph node metastases in relation to tumor histology, tumor location, invasion depth, number of lymph nodes and lymph node metastases, pre-operative diagnostics, neo-adjuvant therapy and survival. Patient-tailored treatment can be developed based on these results, such as the optimal radiation field and extent of lymphadenectomy based on the primary tumor characteristics. TRIAL REGISTRATION: NCT03222895, date of registration: July 19th, 2017. BioMed Central 2019-07-04 /pmc/articles/PMC6610993/ /pubmed/31272485 http://dx.doi.org/10.1186/s12885-019-5761-7 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Study Protocol Hagens, Eliza R. C. van Berge Henegouwen, Mark I. van Sandick, Johanna W. Cuesta, Miguel A. van der Peet, Donald L. Heisterkamp, Joos Nieuwenhuijzen, Grard A. P. Rosman, Camiel Scheepers, Joris J. G. Sosef, Meindert N. van Hillegersberg, Richard Lagarde, Sjoerd M. Nilsson, Magnus Räsänen, Jari Nafteux, Philippe Pattyn, Piet Hölscher, Arnulf H. Schröder, Wolfgang Schneider, Paul M. Mariette, Christophe Castoro, Carlo Bonavina, Luigi Rosati, Riccardo de Manzoni, Giovanni Mattioli, Sandro Garcia, Josep Roig Pera, Manuel Griffin, Michael Wilkerson, Paul Chaudry, M. Asif Sgromo, Bruno Tucker, Olga Cheong, Edward Moorthy, Krishna Walsh, Thomas N. Reynolds, John Tachimori, Yuji Inoue, Haruhiro Matsubara, Hisahiro Kosugi, Shin-ichi Chen, Haiquan Law, Simon Y. K. Pramesh, C. S. Puntambekar, Shailesh P. Murthy, Sudish Linden, Philip Hofstetter, Wayne L. Kuppusamy, Madhan K. Shen, K. Robert Darling, Gail E. Sabino, Flávio D. Grimminger, Peter P. Meijer, Sybren L. Bergman, Jacques J. G. H. M. Hulshof, Maarten C. C. M. van Laarhoven, Hanneke W. M. Mearadji, Banafsche Bennink, Roel J. Annema, Jouke T. Dijkgraaf, Marcel G. W. Gisbertz, Suzanne S. Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study |
title | Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study |
title_full | Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study |
title_fullStr | Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study |
title_full_unstemmed | Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study |
title_short | Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study |
title_sort | distribution of lymph node metastases in esophageal carcinoma [tiger study]: study protocol of a multinational observational study |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610993/ https://www.ncbi.nlm.nih.gov/pubmed/31272485 http://dx.doi.org/10.1186/s12885-019-5761-7 |
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