mTOR as a central regulator of lifespan and aging

The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and proliferation. Although the involvement of the mTOR pathway in regulating life span and aging has been studied extensively...

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Autores principales: Papadopoli, David, Boulay, Karine, Kazak, Lawrence, Pollak, Michael, Mallette, Frédérick A., Topisirovic, Ivan, Hulea, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611156/
https://www.ncbi.nlm.nih.gov/pubmed/31316753
http://dx.doi.org/10.12688/f1000research.17196.1
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author Papadopoli, David
Boulay, Karine
Kazak, Lawrence
Pollak, Michael
Mallette, Frédérick A.
Topisirovic, Ivan
Hulea, Laura
author_facet Papadopoli, David
Boulay, Karine
Kazak, Lawrence
Pollak, Michael
Mallette, Frédérick A.
Topisirovic, Ivan
Hulea, Laura
author_sort Papadopoli, David
collection PubMed
description The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and proliferation. Although the involvement of the mTOR pathway in regulating life span and aging has been studied extensively in the last decade, the underpinning mechanisms remain elusive. In this review, we highlight the emerging insights that link mTOR to various processes related to aging, such as nutrient sensing, maintenance of proteostasis, autophagy, mitochondrial dysfunction, cellular senescence, and decline in stem cell function.
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spelling pubmed-66111562019-07-16 mTOR as a central regulator of lifespan and aging Papadopoli, David Boulay, Karine Kazak, Lawrence Pollak, Michael Mallette, Frédérick A. Topisirovic, Ivan Hulea, Laura F1000Res Review The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and proliferation. Although the involvement of the mTOR pathway in regulating life span and aging has been studied extensively in the last decade, the underpinning mechanisms remain elusive. In this review, we highlight the emerging insights that link mTOR to various processes related to aging, such as nutrient sensing, maintenance of proteostasis, autophagy, mitochondrial dysfunction, cellular senescence, and decline in stem cell function. F1000 Research Limited 2019-07-02 /pmc/articles/PMC6611156/ /pubmed/31316753 http://dx.doi.org/10.12688/f1000research.17196.1 Text en Copyright: © 2019 Papadopoli D et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Papadopoli, David
Boulay, Karine
Kazak, Lawrence
Pollak, Michael
Mallette, Frédérick A.
Topisirovic, Ivan
Hulea, Laura
mTOR as a central regulator of lifespan and aging
title mTOR as a central regulator of lifespan and aging
title_full mTOR as a central regulator of lifespan and aging
title_fullStr mTOR as a central regulator of lifespan and aging
title_full_unstemmed mTOR as a central regulator of lifespan and aging
title_short mTOR as a central regulator of lifespan and aging
title_sort mtor as a central regulator of lifespan and aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611156/
https://www.ncbi.nlm.nih.gov/pubmed/31316753
http://dx.doi.org/10.12688/f1000research.17196.1
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