Protective effect of PCV vaccine against experimental pneumococcal challenge in adults is primarily mediated by controlling colonisation density

Widespread use of Pneumococcal Conjugate Vaccines (PCV) has reduced vaccine-type nasopharyngeal colonisation and invasive pneumococcal disease. In a double-blind, randomised controlled trial using the Experimental Human Pneumococcal Challenge (EHPC) model, PCV-13 (Prevenar-13) conferred 78% protecti...

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Detalles Bibliográficos
Autores principales: German, E.L., Solórzano, C., Sunny, S., Dunne, F., Gritzfeld, J.F., Mitsi, E., Nikolaou, E., Hyder-Wright, A.D., Collins, A.M., Gordon, S.B., Ferreira, D.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611220/
https://www.ncbi.nlm.nih.gov/pubmed/31176540
http://dx.doi.org/10.1016/j.vaccine.2019.05.080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611220/
https://www.ncbi.nlm.nih.gov/pubmed/31176540
http://dx.doi.org/10.1016/j.vaccine.2019.05.080

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