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Protective effect of PCV vaccine against experimental pneumococcal challenge in adults is primarily mediated by controlling colonisation density
Widespread use of Pneumococcal Conjugate Vaccines (PCV) has reduced vaccine-type nasopharyngeal colonisation and invasive pneumococcal disease. In a double-blind, randomised controlled trial using the Experimental Human Pneumococcal Challenge (EHPC) model, PCV-13 (Prevenar-13) conferred 78% protecti...
Autores principales: | German, E.L., Solórzano, C., Sunny, S., Dunne, F., Gritzfeld, J.F., Mitsi, E., Nikolaou, E., Hyder-Wright, A.D., Collins, A.M., Gordon, S.B., Ferreira, D.M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611220/ https://www.ncbi.nlm.nih.gov/pubmed/31176540 http://dx.doi.org/10.1016/j.vaccine.2019.05.080 |
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